Concept

Cœur pulmonaire

Publications associées (33)

Artificial Muscle for End-Stage Heart Failure

Alexandre Michalis, Didier Locca, Ludwig Von Segesser

We describe a device made of artificial muscle for the treatment of end-stage heart failure as an alternative to current heart assist devices. The key component is a matrix of nitinol wires and aramidic fibers called Biometal muscle (BM). When heated elect ...

2012

Expression of the leptin receptor outside of bone marrow-derived cells regulates tuberculosis control and lung macrophage MHC expression

John McKinney

Leptin is a pleiotropic hormone proposed to link nutritional status to the development of strong Th1 immunity. Because Mycobacterium tuberculosis control is affected by starvation and diabetes, we studied the role of the leptin receptor in regulating disti ...

2011

Design of a multi-scale canine-specific model of cardiac electromechanics : a step toward patient-specific modeling

Vincent Forster

Motivated by the growing wealth of biological data and the increasing pathophysiological knowledge at different scales, spectacular progress have been made in comprehensive modeling to understand the complex nature of biological organs, such as the heart. ...

2008

Design and Optimization of a Lactate Amperometric Biosensor based on Lactate Oxidase and Multi Walled-Carbon Nanotubes

Giovanni De Micheli, Sandro Carrara, Cristina Boero

Lactate concentration in physiological fluids is an indicator of the energy production under anaerobic conditions of the whole organism [1]. Normal value for lactate level in blood ranges from 0.5 – 2.5 mM. Blood lactate values exceeding 7-8 mM are sometim ...

2008

Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages

Nicola Harris, Benjamin John Marsland

Chronic obstructive pulmonary disease (COPD) is the 5(th) most prevalent disease worldwide leading to severe morbidity and mortality in developed countries. The disease is strongly associated with smoking, and can be characterized by progressive and irreve ...

2008

Effects of an aging vascular model on healthy and diseased hearts

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, David Jegger, Patrick Segers

The vitamin D(3) and nicotine (VDN) model is a model of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of ...

2007

Beta-catenin downregulation is required for adaptive cardiac remodeling

The armadillo-related protein beta-catenin has multiple functions in cardiac tissue homeostasis: stabilization of beta-catenin has been implicated in adult cardiac hypertrophy, and downregulation initiates heart formation in embryogenesis. The protein is a ...

2007

The non-circular shape of FloWatch®-PAB prevents the need for pulmonary artery reconstruction after banding

Alfio Quarteroni, Paolo Zunino, Ludwig Von Segesser

To evaluate the differences between non-circular shape of FloWatch®-PAB and conventional pulmonary artery (PA) banding. Methods: Geometrical analysis. Conventional banding and FloWatch®-PAB perimeters were plotted against cross-sections. Computational flui ...

Elsevier Science B.V., Oxford2006

Effects of a stiffened arterial tree on ventricular-arterial coupling in healthy and diseased hearts

David Jegger

In this thesis we study ventricular-arterial coupling in rodents under the influence of arterial stiffening and myocardial infarction (MI), combination of the two considered as a novel cardiovascular research model for diseased hearts pumping against an ag ...

EPFL2006

Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter

Nikolaos Stergiopoulos, David Jegger, Patrick Segers

The rodent model of myocardial infarction (MI) is extensively used in heart failure studies. However, long-term follow-up of echocardiographic left ventricular (LV) function parameters such as the myocardial performance index (MPI) and its ratio with the f ...

2005

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