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Publications associées (83)

Risk and Reward Perception in the Human Brain

The recent spate of neuroimaging studies on decision-making under uncertainty has provided converging evidence of a spatio-temporal dissociation of risk and expected reward encoding in the human brain. While this research has demonstrated widespread hemody ...

University of Zurich2007

Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates

Patrick Aebischer, Bernard Schneider

Glial cell line-derived neurotrophic factor (GDNF) has been shown to increase the survival and functioning of dopamine neurons in a variety of animal models and some recent human trials. However, delivery of any protein to the brain remains a challenge due ...

2006

Proton MRS of the unilateral substantia nigra in the human brain at 4 tesla: Detection of high GABA concentrations

Rolf Gruetter

Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra (SN), the cause of which is unknown. Characterization of early SN pathology could prove beneficial in the treatment and diagnosis of PD. The present study sho ...

2006

Dopaminergic fiber protection and regeneration by Wlds protein and GDNF in rodent models of Parkinson disease

Ali Etemad-Sajadi

Parkinson disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. The resulting failure of the nigrostriatal pathway leads to profound dopamine deficiency, cau ...

EPFL2005

Atlas-based segmentation of medical images locally constrained by level sets

Jean-Philippe Thiran, Valérie Duay, Nawal Houhou

Atlas-based segmentation has become a standard paradigm for exploiting prior knowledge in medical image segmentation. In this paper, we propose a method to exploit both the robustness of global registration techniques and the accuracy of a local registrati ...

2005

ATLAS-BASED SEGMENTATION OF MEDICAL IMAGES LOCALLY CONSTRAINED BY LEVEL SETS

Jean-Philippe Thiran, Valérie Duay, Nawal Houhou

IEEE2005

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

Patrick Aebischer

Glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor with restorative effects in a variety of rodent and primate models of Parkinson's disease (PD), could be of therapeutic value to PD. In this study, we show that intraventricul ...

2004

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

Patrick Aebischer, Bernard Schneider, Manuel Bauer, Christophe Lo Bianco

Parkinson's disease (PD) is characterized by a progressive loss of midbrain dopamine neurons and the presence of cytoplasmic inclusions called Lewy bodies. Mutations in several genes including alpha-synuclein and parkin have been linked to familial PD. The ...

2004

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

Hilal Lashuel

Protein misfolding and aggregation have been linked to several human diseases, including Alzheimer's disease, Parkinson's disease, and systemic amyloidosis, by mechanisms that are not yet completely understood. The hallmark of most of these diseases is the ...

National Academy of Sciences2003

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration

Patrick Aebischer

The primate striatum contains tyrosine hydroxylase (TH)-immunoreactive (ir) neurons, the numbers of which are augmented after dopamine depletion. Glial cell line-derived neurotrophic factor (GDNF) strongly modulates the viability and phenotypic expression ...

2002

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