Concept

Development of the cerebral cortex

Publications associées (59)

Enhancement of brain atlases with region-specific coordinate systems: flatmaps and barrel column annotations

Michael Reimann, Sirio Bolaños Puchet, Aleksandra Zuzanna Teska

Digital brain atlases define a hierarchy of brain regions and their locations in three-dimensional space. They provide a standard coordinate system in which diverse datasets can be integrated for visualization and analysis. They also enable building of dat ...

2023

Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles

Alexey Sapozhnik, Samuel Jones

JC polyomavirus (JCPyV) is an opportunistic virus that remains in a latent state in the kidneys and lymphoid organs of more than half of the human adult population. In rare cases of severe immune suppression, the virus is able to establish a lytic infectio ...

Washington2023

Of mice and men: Increased dendritic complexity gives rise to unique human networks

Henry Markram, Kathryn Hess Bellwald, Lida Kanari, Alexis Arnaudon, Ying Shi, Jay Coggan, Natali Barros Zulaica, Idan Segev, Ruth Benavides Piccione

The organizational principles that distinguish the human brain from those of other species have been a long-standing enigma in neuroscience. Here, we leverage advances in algebraic topology to uncover the structural properties of the human brain at subcell ...

bioRxiv2023

The Target of Exuberant Projections in Development

Giorgio Innocenti

In addition to neuronal death and elimination of synapses, the production of transient, exuberant axons, and axonal branches is a general phenomenon in development across species and systems. To understand what drives the decision of which axons are mainta ...

2020

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

Tobias Kober, Bénédicte Marie Maréchal, Mario Joao Fartaria de Oliveira

Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease prog ...

2020

Synaptic patterning and the timescales of cortical dynamics

Alexander Kevin Seeholzer

Neocortical circuits, as large heterogeneous recurrent networks, can potentially operate and process signals at multiple timescales, but appear to be differentially tuned to operate within certain temporal receptive windows. The modular and hierarchical or ...

Elsevier2017

Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex

Lida Kanari, Idan Segev, Guy Antoine Atenekeng Kahou, Guy Eyal, Yair Deitcher

There have been few quantitative characterizations of the morphological, biophysical, and cable properties of neurons in the human neocortex. We employed feature-based statistical methods on a rare data set of 60 3D reconstructed pyramidal neurons from L2 ...

Oxford University Press2017

The cerebral wall of the human fetal brain is composed of transient cellular compartments, which show characteristic spatiotemporal relationships with major neurogenic events (proliferation, migration, axonal growth, dendritic differentiation, synaptogenes ...

Frontiers Research Foundation2016

Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irreversibility is clearly defined. Here we ...

Inst Biochemistry & Cell Biology2016

Quantitative activity-induced manganese-dependent MRI for characterizing cortical layers in the primary somatosensory cortex of the rat

Rolf Gruetter, Mario Gaetano Lepore, Nathalie Just, Matthieu Pierre Auffret, Idrees Samim

The ability of Mn2+ to follow Ca2+ pathways upon stimulation transform them into remarkable surrogate markers of neuronal activity using activity-induced manganese-dependent MRI (AIM–MRI). In the present study, a precise follow-up of physiological paramete ...

Springer Heidelberg2016

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