Concept
Œdème cérébral
Publications associées (140)
Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
Pierre Magistretti, Luc Pellerin
Recent evidence suggests that lactate could be a preferential energy substrate transferred from astrocytes to neurons. This would imply the presence of specific transporters for lactate on both cell types. We have investigated the immunohistochemical local ...
2000Increased focal interictal discharges during specific cognitive tasks
We present a patient with pharmacoresistant right temporal lobe epilepsy who showed a significant increase in focal interictal spikes in response to specific visuospatial tasks, Temporal spiking was particularly increased during immediate recall of visuosp ...
Taylor & Francis1999Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog
A noninvasive test is needed to assess the severity of encephalopathy during fulminant hepatic failure. This feasibility study was designed to compare a noninvasive test, brain lactate measurement by magnetic resonance spectroscopy, with intracranial press ...
1998Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR
The peak at 3.35 ppm in the 1H-NMR spectrum characteristic for scyllo- inositol may be a marker for cerebral pathology, although it has a well- known constant concentration relative to myo-inositol. Such a peak was observed with an intensity at least 300% ...
1998Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
Pierre Magistretti, Jean-Luc Martin, Luc Pellerin
Mounting evidence from in vitro experiments indicates that lactate is an efficient energy substrate for neurons and that it may significantly contribute to maintain synaptic transmission, particularly during periods of intense activity. Since lactate does ...
1998Resolution Improvements in in Vivo 1H NMR Spectra with Increased Magnetic Field Strength
The measurement of cerebral metabolites using highly homologous localization techniques and similar shimming methods was performed in the human brain at 1.5 and 4 T as well as in the dog and rat brain at 9.4 T. In rat brain, improved resolution was achieve ...
1998Metabolic coupling during activation: A cellular view
Pierre Magistretti, Luc Pellerin
A tight coupling exists between neuronal activity and energy metabolism. Over a century ago Roy and Sherrington postulated that “the brain possesses intrinsic mechanisms by which its vascular supply can be varied locally in correspondence with local variat ...
1997The problems of delivering neuroactive molecules to the CNS
At present, the aetiologies of many neurological and neurodegenerative diseases are unknown. However, emergence of a better understanding of these diseases, at both cellular and molecular levels, opens up the possibility of replacement therapies. The prese ...
1996Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose
Cerebral metabolism of D[1-13C]glucose was studied with localized 13C NMR spectroscopy during intravenous infusion of enriched [1-13C]glucose in four healthy subjects. The use of three-dimensional localization resulted in the complete elimination of triacy ...
1994Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy
Glucose is the main fuel for energy metabolism in the normal human brain. It is generally assumed that glucose transport into the brain is not rate-limiting for metabolism. Since brain glucose concentrations cannot be determined directly by radiotracer tec ...
National Academy of Sciences1992