Publications associées à Voie méso-limbique

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Graham Knott, Liliane Glauser, Elpida Tsika, Darren Moore, Shi-Yan Caroline Foo, Meghna Kannan

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heter ...

Elsevier2014

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Bernard Schneider, Liliane Glauser, Elpida Tsika, Darren Moore, Guillaume Daniel, Aris Nikolaos Fiser

Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the ...

Oxford University Press2014

Baseline frontostriatal-limbic connectivity predicts reward-based memory formation

Friedhelm Christoph Hummel

Reward mediates the acquisition and long-term retention of procedural skills in humans. Yet, learning under rewarded conditions is highly variable across individuals and the mechanisms that determine interindividual variability in rewarded learning are not ...

Wiley-Blackwell2014

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

Bernard Schneider, Pamela Solange Valdés Undurraga

Parkinson disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc). Although growing evidence indicates that endoplasmic reticulum (ER) stress is a hallmark of PD, its exact contribution to th ...

National Academy of Sciences2014

FOXO3 determines the accumulation of alpha-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

Bernard Schneider, Graham Knott, Juan-Carlos Sarria, Lu Zheng, Emilda Pino, Ryoji Amamoto

Parkinson's disease (PD) is characterized by the selective degeneration of neuronal populations presumably due to pathogenic interactions between aging and predisposing factors such as increased levels of a-synuclein. Here, we genetically modulate the acti ...

Oxford University Press2014

Neurofeedback-mediated self-regulation of the dopaminergic midbrain

Roger Gassert, Maria Laura Blefari

The dopaminergic system is involved in reward encoding and reinforcement learning. Dopaminergic neurons from this system in the substantia nigra/ventral tegmental area complex (SN/VTA) fire in response to unexpected reinforcing cues. The goal of this study ...

Elsevier2013

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Rolf Gruetter, Patrick Aebischer, Bernard Schneider, Philippe Guillaume Coune, Mélanie Craveiro, Meret Gaugler

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently ...

Wiley-Blackwell2013

Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa, Alec Ginggen

Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects. We tested the hypot ...

2013

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Voie méso-limbique

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Baseline frontostriatal-limbic connectivity predicts reward-based memory formation

Exploring the pathological interaction between LRRK2 and alpha-synuclein

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

FOXO3 determines the accumulation of alpha-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

Crowdsourcing Literal Review

Neurofeedback-mediated self-regulation of the dopaminergic midbrain

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model

Graph Chatbot

Chattez avec Graph Search

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Crowdsourcing Literal Review

Baseline frontostriatal-limbic connectivity predicts reward-based memory formation

Neurofeedback-mediated self-regulation of the dopaminergic midbrain

Exploring the pathological interaction between LRRK2 and alpha-synuclein

FOXO3 determines the accumulation of alpha-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model