Publications associées à Heart development

Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Andrew Charles Oates, Mahmut Selman Sakar, Ece Özelçi, Erik Mailand, Matthias Rüegg

Classic microsurgical techniques, such as those used in the early 1900s by Mangold and Spemann, have been instrumental in advancing our understanding of embryonic development. However, these techniques are highly specialized, leading to issues of inter-ope ...

Nature Research2022

Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart

Alfio Quarteroni

Before septation processes shape its four chambers, the embryonic heart is a straight tube that spontaneously bends and twists breaking the left-right symmetry. In particular, the heart tube is subjected to a cell remodeling inducing ventral bending and de ...

SIAM PUBLICATIONS2021

Capturing Cardiogenesis in Gastruloids

Matthias Lütolf, Romain Guiet, Nicolas Antoine Vincent Broguiere, Giuliana Rossi, Andrea Boni, Mehmet Ugur Girgin

Organoids are powerful models for studying tissue development, physiology, and disease. However, current culture systems disrupt the inductive tissue-tissue interactions needed for the complex morphogenetic processes of native organogenesis. Here, we show ...

CELL PRESS2021

Tissue Engineering with Mechanically Induced Solid‐Fluid Transitions

Mahmut Selman Sakar, Ece Özelçi, Jaemin Kim, Erik Mailand, Nikolaos Bouklas, Matthias Rüegg, Jon Märki, Odysseas Konstantinos Chaliotis

Epithelia are contiguous sheets of cells that stabilize the shape of internal organs and support their structure by covering their surfaces. They acquire diverse morphological forms appropriate for their specific functions during embryonic development, suc ...

Wiley2021

The emergence and promise of single-cell temporal-omics approaches

Gioele La Manno, Alex Russell Lederer

Single-cell transcriptomics enables the measurement of gene expression in complex biological systems at the resolution of individual cells. Multivariate analysis of single-cell data helps describe the variation in expression accompanying cellular processes ...

CURRENT BIOLOGY LTD2020

Computational Analysis of Turbulent Hemodynamics in Radiocephalic Arteriovenous Fistulas to Determine the Best Anastomotic Angles

Alfio Quarteroni, Christian Vergara

Background: Hemodynamics has been known to play a major role in the development of intimal hyperplasia leading to arteriovenous fistula failure. The goal of our study is to investigate the influence of different angles of side-to-end radiocephalic anastomo ...

ELSEVIER SCIENCE INC2020

Feasibility of neurochemically profiling mouse embryonic brain and its development in utero using 1 H MRS at 14.1 T

Hongxia Lei, Sébastien Robert Victor Herzig

We aimed to evaluate the feasibility of neurochemical profiling of embryonic mouse brain developments in utero and to seek potential in vivo evidence of an energy shift in a mitochondrial pyruvate carrier 1 (MPC1) deficient mouse model. C57BL/6 embryonic m ...

2019

Embryonic lateral inhibition as optical modes: An analytical framework for mesoscopic pattern formation

Andrew Charles Oates, Jose Negrete Jr

Cellular checkerboard patterns are observed at many stages of embryonic development. We study an analytically tractable model for lateral inhibition and show that the steady states are analogous to optical phonons at the Gamma point, which have the wave nu ...

2019

A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Nikolaos Stergiopoulos, Patrick Segers

Arterial rupture in horses has been observed during exercise, after phenylephrine administration or during parturition (uterine artery). In human pathophysiological research, the use of computer models for studying arterial hemodynamics and understanding n ...

2019

Robust Baseline Measurement for Reliable Fetal Heart Rate Evaluation

Guglielmo Frigo

Cardiotocography is a measurement technique widely adopted to assess fetal well-being during both antepartum and intra-partum stages. It consists of two simultaneously acquired time-series: fetal heart rate and uterine activity. Since visual inspection ana ...

IEEE2018