Concept

Acide xénonucléique

Publications associées (7)

Distinguishing dopamine and calcium responses using XNA-nanotube sensors for improved neurochemical sensing

Ardemis Anoush Boghossian, Melania Reggente, Alice Judith Gillen, Alessandra Antonucci, Daniel Eduardo Morales Garza

To date, the engineering of single-stranded DNA-SWCNT (DNA-SWCNT) optical biosensors have largely focused on creating sensors for new applications with little focus on optimising existing sensors for in vitro and in vivo conditions. Recent studies have sho ...

2021

Xeno Nucleic Acid Nanosensors for Enhanced Stability Against Ion-Induced Perturbations

Ardemis Anoush Boghossian, Carlo Gigli, Alice Judith Gillen, Justyna Kupis-Rozmyslowicz

The omnipresence of salts in biofluids creates a pervasive challenge in designing sensors suitable for in vivo applications. Fluctuations in ion concentrations have been shown to affect the sensitivity and selectivity of optical sensors based on single-wal ...

2018

Synthesis of Glycomimetics as Potential Anti-Cancer Agents

Annabelle Gillig

Cancer cells exhibit different properties that make them dangerous to the host, such as the ability to invade other tissues and the abnormal response to the control mechanisms that regulate the division of normal cells, which allow them to divide in a rela ...

EPFL2010

Real-Time Bioluminescence Imaging of Glycans on Live Cells

Cell-surface glycans are attractive targets for molecule imaging due to their reflection of cellular processes associated with development and disease progression. In this paper, we describe the design, synthesis, and biological application of a new phosph ...

American Chemical Society2010

Conformational analysis of nucleic acids revisited: Curves

John Maddocks, Daiva Petkeviciute

We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones. The program is algori ...

Oxford University Press2009

RNA-sequence or nucleoside/nucleotide analogues and method for producing the analogues

Sébastien Porcher

Nucleic acid sequence analogues, in particular tRNA analogues comprising in the place of a 3'-terminal adenosine a 3'-terminal 2'-deoxy-2'-thioadenosine are able to react site-specifically with weakly activated amino acid derivatives (e.g. phenylthioesters ...

2006

Chemistry of a-aminonitriles. Part 13. Formation of 2-oxoethyl phosphates ('glycolaldehyde phosphates') from rac-oxiranecarbonitrile and inorganic phosphate and on (formal) constitutional relationships between 2-oxoethyl phosphates and oligo(hexo- and pentopyranosyl)nucleotide backbones

Oxiranecarbonitrile in basic aq. soln. at room temp. reacts regioselectively with inorg. phosphate to give the cyanohydrin of 2-oxoethyl phosphate ('glycolaldehyde phosphate'), a source of (the hydrate of) the free aldehyde, preferably in the presence of f ...

1994

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