Concept
Uracile
Publications associées (14)
NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism
Vassily Hatzimanikatis, Jasmin Maria Hafner, Homa Mohammadi Peyhani, Noushin Hadadi, Anush Chiappino-Pepe
The discovery of a drug requires over a decade of intensive research and financial investments – and still has a high risk of failure. To reduce this burden, we developed the NICEdrug.ch resource, which incorporates 250,000 bioactive molecules, and studied ...
2021Photophysics and Photochemistry of a DNA–Protein Cross-Linking Model: A Synergistic Approach Combining Experiments and Theory
Ursula Röthlisberger, Ivano Tavernelli, Sara Bonella, Mohammadhassan Valadan
The photophysical and photochemical properties of 5-benzyluracil and 5,6-benzyluracil, the latter produced by photocyclization of the former through irradiation with femtosecond UV laser pulses, are investigated both experimentally and theoretically. The a ...
2014Assessing the cellular uptake pathway for poly-Lysine analogues using triplet lifetime imaging
Dimitri Nestor Alice Van De Ville, Theo Lasser, Harm-Anton Klok, Iwan Märki, Zuzana Kadlecova
Research on synthetic delivery vectors is of major interest for cell imaging and manipulation, as they allow an efficient transfer of nucleic acids, therapeutic proteins or small drugs into the cells. We have developed a library of L-lysine analogues that ...
2011DNA Topology
This thesis explores different aspects of DNA topology through experimental and numerical techniques. Topology is a vast mathematical field, that deals with the spatial properties of objects undergoing continuous deformations, but here it is restricted to ...
EPFL2010