Concept
Réplication circulaire de l'ADN
Publications associées (65)
Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system
One of the goals of synthetic biology is the development of an artificial cell. Building an artificial cell from scratch will provide a deeper understanding of fundamental mechanisms and models in biology and promises to contribute towards building novel p ...
EPFL2024Chromosome organization shapes replisome dynamics in Caulobacter crescentus
Suliana Manley, Chen Zhang, Laurent Casini
DNA replication in bacteria takes place on highly compacted chromosomes, where segregation, transcription, and repair must occur simultaneously. Within this dynamic environment, colocalization of sister replisomes has been observed in many bacterial specie ...
Nature Portfolio2024C2CAplus: A One-Pot Isothermal Circle-to-Circle DNA Amplification System
Sebastian Maerkl, Laura Sophie Grasemann
Rolling circle amplification (RCA) is a widely used DNA amplification method that uses circular template DNA as input and produces multimeric, linear single- or double-stranded DNA. Circle-to-circle amplification (C2CA) has further expanded this method by ...
Washington2023Single photon detection with amorphous silicon-based microchannel plates: A Monte Carlo model
Christophe Ballif, Jonathan Emanuel Thomet, Janina Christine Isabelle Löffler, Samira Alexandra Frey
Microchannel plates based on amorphous silicon have the inherent capability to overcome the existing spatial and temporal resolution limitations of single photon detectors. A Monte Carlo model-based study is presented here that serves to exploit their full ...
2022Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry
Sevan Mleh Habeshian, Ying Zhang
Libraries of DNA-Encoded small molecules created using combinatorial chemistry and synthetic oligonucleotides are being applied to drug discovery projects across the pharmaceutical industry. The majority of reported projects describe the discovery of rever ...
PERGAMON-ELSEVIER SCIENCE LTD2021The human telomeric proteome during telomere replication
Joachim Lingner, Thomas Frédéric Lunardi, Aleksandra Vancevska, Gérald Joseph Paul Lossaint, Chih-Yi Gabriela Lin
Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the sem ...
OXFORD UNIV PRESS2021Virus lasers for biological detection
The selective amplification of DNA in the polymerase chain reaction is used to exponentially increase the signal in molecular diagnostics for nucleic acids, but there are no analogous techniques for signal enhancement in clinical tests for proteins or cell ...
Springer2019