Publications associées à Epigenetic clock

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Johan Auwerx, Richardus Houtkooper, Maroun Bou Sleiman, Xu Wang, Pooja Jha

Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and ag ...

2020

Comprehensive analysis of PM20D1 QTL in Alzheimer's disease

Johannes Gräff, Liliane Glauser, Jose Vicente Sanchez Mut

Background Alzheimer's disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Genetic and epigenetic factors are not ind ...

BMC2020

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Li Tang, George Coukos, Marcela Rincón-Restrepo, Nicola Vannini, Min Gao, Fabien Franco

Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction. The metabolic challenges present in tumors a ...

2020

Basic creep of cement paste at early age - the role of cement hydration

Karen Scrivener, Pietro Lura

In this work, the uniaxial creep in compression during the first days of hydration is studied experimentally on cement pastes with w/c of 0.50. to order to assess the effect of the evolving microstructure on creep, the so-called equivalent systems are empl ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

Jian Wang, Henning Paul-Julius Stahlberg, Amanda Jennifer Lewis

Parkinson's disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy bodies and Lewy neurites: neuronal inclusions immunopositive for the protein alph ...

Springer Science and Business Media LLC2019

ZNF445 is a primary regulator of genomic imprinting

Didier Trono, Priscilla Turelli, Christian Axel Wandall Thorball, Evaristo Jose Planet Letschert, Sandra Eloise Kjeldsen, Michaël Imbeault, Andrea Coluccio

Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertil ...

2019

Methods of diagnosis alzheimer's disease

Johannes Gräff, Jose Vicente Sanchez Mut

A method for the diagnosis or prognosis of Alzheimer's disease (AD), includes the steps of placing a sample isolated from a person suspected of having AD onto a substrate labeling the sample to identify at least one epigenetic marker and/or genetic variati ...

2018

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Ume-Gulsoom Abdul, Marije Trudi Te Winkel

Cancer cells are often dependent on epigenetic pathways for their survival. Consequently, drugs that target the epigenome, rather than the underlying DNA sequence, are currently attracting considerable attention. In recent years, the first epigenetic drugs ...

Springer Verlag2017

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Epigenetic clock

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Comprehensive analysis of PM20D1 QTL in Alzheimer's disease

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer

Basic creep of cement paste at early age - the role of cement hydration

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

ZNF445 is a primary regulator of genomic imprinting

Methods of diagnosis alzheimer's disease

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment

Graph Chatbot

Chattez avec Graph Search

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Comprehensive analysis of PM20D1 QTL in Alzheimer's disease

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer

Basic creep of cement paste at early age - the role of cement hydration

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

ZNF445 is a primary regulator of genomic imprinting

Methods of diagnosis alzheimer's disease

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment