Concept
Nuclear gene
Publications associées (35)
Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome
Mutations in nuclear-encoded mitochondrial genes are responsible for a broad spectrum of disorders among which Leigh syndrome is the most common in infancy. No effective therapies are available for this severe disease mainly because of the limited capabili ...
2020MicroRNA-204-5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans
Using an unbiased high-throughput microRNA (miRNA)-silencing screen combined with functional readouts for mitochondrial oxidative capacity in C2C12 myocytes, we previously identified 19 miRNAs as putative regulators of skeletal muscle mitochondrial metabol ...
2020Mitonuclear communication in homeostasis and stress
Johan Auwerx, Adrienne Joëlle Laurence Mottis
Mitochondria participate in crucial cellular processes such as energy harvesting and intermediate metabolism. Although mitochondria possess their own genome - a vestige of their bacterial origins and endosymbiotic evolution - most mitochondrial proteins ar ...
Nature Publishing Group2016