Concept
Axe intestin-cerveau
Publications associées (83)
Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
Cristina Ramona Cudalbu, Jocelin Grosse, Veronika Rackayová, Emmanuelle Ines Flatt
Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora ...
2021Biogeography of microbial bile acid transformations along the murine gut
Rizlan Bernier-Latmani, Laure Menin, Solenne Anne Marie Marion, Lyne Desharnais
Bile acids, which are synthesized from cholesterol by the liver, are chemically transformed along the intestinal tract by the gut microbiota, and the products of these transformations signal through host receptors, affecting overall host health. These tran ...
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2020Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling
Asperuloside (ASP) is an iridoid glycoside that is extracted from Eucommia leaves. Eucommia is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metab ...
2020Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids
The gut microbiome has been linked to fear extinction learning in animal models. Here, we aimed to explore the gut microbiome and memory domains according to obesity status. A specific microbiome profile associated with short-term memory, working memory, a ...
CELL PRESS2020Biogeography and biochemistry of bile acid 7-dehydroxylation in the mammalian gut
Bile acids (BAs) are small molecules synthesized by the host and chemically modified by the microorganisms inhabiting the intestinal tract. The microbial transformation of BAs in the gut is critical to BA-mediated signaling as it modifies their amount and ...
EPFL2020Antibiotics-induced monodominance of a novel gut bacterial order
Christoph Merten, Sebastian Martin Waszak
Objective the composition of the healthy human adult gut microbiome is relatively stable over prolonged periods, and representatives of the most highly abundant and prevalent species have been cultured and described. However, microbial abundances can chang ...
2020Multicenter analysis of sputum microbiota in tuberculosis patients
Stewart Cole, Jacques Rougemont, Marion Leleu, Claudia Sala, Andrej Benjak, Philippe Busso
The impact of tuberculosis and of anti-tuberculosis therapy on composition and modification of human lung microbiota has been the object of several investigations. However, no clear outcome has been presented so far and the relationship betweenM.tuberculos ...
2020Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations
Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu, Hongxia Lei, Dunja Simicic, Veronika Rackayová
Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower ...
WILEY2020Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks
The rhythmic and sequential segmentation of the vertebrate body axis into somites during embryogenesis is governed by a multicellular, oscillatory patterning system called the segmentation clock. Despite many overt similarities between vertebrates, differe ...
2020Confounding factors from inducible systems for spatiotemporal gene expression regulation
Johan Auwerx, Richardus Houtkooper
Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect whole-organism physiology and function due to off-target effects. We hig ...
ROCKEFELLER UNIV PRESS2020