Publications associées à Neovascularization

Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model

Hubert van den Bergh, Georges Wagnières, Laurent Décosterd, Jean Yannis Perentes

Solid tumors are known to have an abnormal vasculature that limits the distribution of chemotherapy. We have recently shown that tumor vessel modulation by low-dose photodynamic therapy (L-PDT) could improve the uptake of macromolecular chemotherapeutic ag ...

Elsevier Science Inc2014

PHD2 regulates arteriogenic macrophages through TIE2 signalling

Michele De Palma, Mario Leonardo Squadrito, Ferdinando Pucci

Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, whi ...

Wiley-Blackwell2013

Proteolytic Processing Regulates Placental Growth Factor Activities

Jeffrey Alan Hubbell, Stéphanie Elisabeth Metzger, Martin Ehrbar, Manuel Koch

Placental growth factor (PlGF) is a critical mediator of blood vessel formation, yet mechanisms of its action and regulation are incompletely understood. Here we demonstrate that proteolytic processing regulates the biological activity of PlGF. Specificall ...

Amer Soc Biochemistry Molecular Biology Inc2013

Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis

Patrycja Nowak-Sliwinska

Heparan sulfate (HS), a long linear polysaccharide, is implicated in various steps of tumorigenesis, including angiogenesis. We successfully interfered with HS biosynthesis using a peracetylated 4-deoxy analogue of the HS constituent GlcNAc and studied the ...

Amer Chemical Soc2013

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

Photodynamic therapy for polypoidal choroidal vasculopathy

Hubert van den Bergh, Patrycja Nowak-Sliwinska

The first effective therapy for exudative macular degeneration (AMD) was Photodynamic Therapy (PDT). Diagnosis of the disease was to a large extent by fluorescein angiography (FA). Distinguishing between the leaky choroidal neovessels (CNV) associated with ...

Pergamon-Elsevier Science Ltd2013

Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches

Michele De Palma, Mario Leonardo Squadrito

The ability of macrophages to promote vascular growth has been associated with the secretion and local delivery of classic proangiogenic factors (e.g., VEGF-A and proteases). More recently, a series of studies have also revealed that physical contact of ma ...

Elsevier Inc2013

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Witold Waldemar Kilarski, Marcin Stefan Zielinski

Therapeutic regulation of tissue vascularization has appeared as an attractive approach to treat a number of human diseases. In vivo neovascularization assays that reflect physiological and pathological formation of neovessels are important in this effort. ...

Springer Netherlands2012

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Blaise Lovisa

Targeted angiostatic therapy receives major attention for the treatment of cancer and exudative age-related macular degeneration (AMD). Photodynamic therapy (PDT) has been used as an effective clinical approach for these diseases. Since PDT can cause an an ...

2012

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Neovascularization

Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model

PHD2 regulates arteriogenic macrophages through TIE2 signalling

Proteolytic Processing Regulates Placental Growth Factor Activities

Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Photodynamic therapy for polypoidal choroidal vasculopathy

Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Disruption of notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice

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Chattez avec Graph Search

Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis

Disruption of notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice

Proteolytic Processing Regulates Placental Growth Factor Activities

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Photodynamic therapy for polypoidal choroidal vasculopathy

PHD2 regulates arteriogenic macrophages through TIE2 signalling

Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches