Publications associées à BRCA1

Arene ruthenium dichloro complexes containing isonicotinic ester ligands: Synthesis, molecular structure and cytotoxicity

Paul Joseph Dyson, Olivier Pierre Zava

A series of p-cymene ruthenium dichloro complexes containing isonicotinic ester ligands, [(arene) RuCl2NC5H4-4-COO-C6H4-p-O-(CH2)(n)-CH3] (n = 1: 1, n = 3: 2, n = 5: 3, n = 7:4, n = 9: 5, n = 11: 6, n = 13: 7, n = 15: 8), were prepared from p-cymene ruthen ...

Elsevier2013

Ruthenium(II) arene PTA (RAPTA) complexes: impact of enantiomerically pure arene ligands

Paul Joseph Dyson, Catherine Marie Amélie Clavel, Kelly Joan Kilpin, Shona Cammack

Organometallic ruthenium(II) arene complexes containing the PTA ligand ([Ru(eta(6)-arene)Cl-2(PTA)], PTA = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1] decane, termed RAPTA) show pharmacologically relevant antitumour properties in vitro. Two new enantiomeric p ...

Royal Society of Chemistry2013

Cutaneous Notch Signaling in Health and Disease

Freddy Radtke, Craig Nowell

The development and maintenance of the skin are dependent on myriad signaling pathways that regulate a variety of cellular processes. In cutaneous epithelial cells, the Notch cascade plays a central role in ensuring that proliferation and differentiation a ...

Cold Spring Harbor Lab Press, Publications Dept2013

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Paul Joseph Dyson, Olivier Pierre Zava

Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrG) or alcohol (pyr(Gn center dot OH)) (n = 1-3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metalla ...

2012

Thiolato-bridged arene-ruthenium complexes: synthesis, molecular structure, reactivity and anticancer activity of the dinuclear complexes [(arene)2Ru2(SR)2C12]

Paul Joseph Dyson, Olivier Pierre Zava

Treatment of an areneruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene)2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and charac ...

Wiley-Blackwell2012

Electrochemical Detection of Anti-Breast-Cancer Agents in Human Serum by Cytochrome P450-Coated Carbon Nanotubes

Giovanni De Micheli, Sandro Carrara, Camilla Baj-Rossi

We report on the electrochemical detection of anti-cancer drugs in human serum with sensitivity values in the range of 8–925 nA/µM. Multi-walled carbon nanotubes were functionalized with three different cytochrome P450 isoforms (CYP1A2, CYP2B6, and CYP3A4) ...

2012

Highly cytotoxic trithiophenolatodiruthenium complexes of the type [(eta(6)-p-MeC6H4Pr (i) )(2)Ru-2(SC6H4-p-X)(3)](+): synthesis, molecular structure, electrochemistry, cytotoxicity, and glutathione oxidation potential

Paul Joseph Dyson, Olivier Pierre Zava, Mathurin Baquié

A series of cationic dinuclear p-cymene ruthenium trithiophenolato complexes of the type (eta(6)-p-MeC6H4Pr (i) )(2)Ru-2(SC6H4-p-X)(3) (1 X is H, 2 X is Me, 3 X is Ph, 4 X is Br, 5 X is OH, 6 X is NO2, 7 X is OMe, 8 X is CF3, 9 X is F, 10 X is Pr (i) ...

2012

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

Emilie Gesina

The absence of the transcriptional repressor RE-1 Silencing Transcription Factor (REST) in insulin-secreting beta cells is a major cue for the specific expression of a large number of genes. These REST target genes were largely ascribed to a function of ne ...

Public Library of Science2012

Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1

Michael Graetzel, Shaik Mohammed Zakeeruddin, Rosario Scopelliti, Angela Casini, Fabio Edafe, Maria Serratrice

The new gold(III) complexes: [Au{2-(2'-pyridyl) imidazolate}Cl-2] and [Au{2,6-bis(2'-benzimidazolate) pyridine}(OCOCH3)] and the mono-and binuclear gold(I) complexes: Au{2-(2'-pyridyl) imidazole} (PPh3), [Au(2-phenylimidazolate)(DAPTA)] (DAPTA = 3,7 ...

Royal Society of Chemistry2012

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BRCA1

Arene ruthenium dichloro complexes containing isonicotinic ester ligands: Synthesis, molecular structure and cytotoxicity

Ruthenium(II) arene PTA (RAPTA) complexes: impact of enantiomerically pure arene ligands

Cutaneous Notch Signaling in Health and Disease

Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(eta(6)-p-phenylethacrynate)Cl-2(pta)]

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Thiolato-bridged arene-ruthenium complexes: synthesis, molecular structure, reactivity and anticancer activity of the dinuclear complexes [(arene)2Ru2(SR)2C12]

Electrochemical Detection of Anti-Breast-Cancer Agents in Human Serum by Cytochrome P450-Coated Carbon Nanotubes

Highly cytotoxic trithiophenolatodiruthenium complexes of the type [(eta(6)-p-MeC6H4Pr (i) )(2)Ru-2(SC6H4-p-X)(3)](+): synthesis, molecular structure, electrochemistry, cytotoxicity, and glutathione oxidation potential

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1

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Chattez avec Graph Search

Electrochemical Detection of Anti-Breast-Cancer Agents in Human Serum by Cytochrome P450-Coated Carbon Nanotubes

Arene ruthenium dichloro complexes containing isonicotinic ester ligands: Synthesis, molecular structure and cytotoxicity

Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1

Cutaneous Notch Signaling in Health and Disease

Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(eta(6)-p-phenylethacrynate)Cl-2(pta)]

Ruthenium(II) arene PTA (RAPTA) complexes: impact of enantiomerically pure arene ligands

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Highly cytotoxic trithiophenolatodiruthenium complexes of the type [(eta(6)-p-MeC6H4Pr (i) )(2)Ru-2(SC6H4-p-X)(3)](+): synthesis, molecular structure, electrochemistry, cytotoxicity, and glutathione oxidation potential

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

Thiolato-bridged arene-ruthenium complexes: synthesis, molecular structure, reactivity and anticancer activity of the dinuclear complexes [(arene)2Ru2(SR)2C12]