Concept
Renal cell carcinoma
Publications associées (129)
Assessment of Stiffness of Large to Small Arteries in Multistage Renal Disease Model: A Numerical Study
Nikolaos Stergiopoulos, Vasiliki Bikia, Patrick Segers
Arterial stiffness (AS), as assessed via pulse wave velocity (PWV), is a major biomarker for cardiovascular risk assessment in patients with chronic kidney disease (CKD). However, the mechanisms responsible for the changes in PWV in the presence of kidney ...
FRONTIERS MEDIA SA2022Rectilinear translation four-bar flexure mechanism based on four Remote Center Compliance pivots
Simon Nessim Henein, Charles Baur, Loïc Benoît Tissot-Daguette, Hubert Pierre-Marie Benoît Schneegans, Quentin Gubler
This paper presents a novel planar four-bar linkage compliant mechanism (called 4-RCC) based on four flexure-based Remote Center of Compliance (RCC) pivots. With particular configurations and dimensions, the beam shortening of the RCC pivots can compensate ...
euspen2022Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes
Maxim Norkin, Paloma Ordonez Moran
The genomes of many human CRCs have been sequenced, revealing a large number of genetic alterations. However, the molecular mechanisms underlying the accumulation of these alterations are still being debated. In this study, we examined colorectal tumours ...
2021Next-generation cancer organoids
Matthias Lütolf, Nicolas Antoine Vincent Broguiere
Organotypic models of patient-specific tumours are revolutionizing our understanding of cancer heterogeneity and its implications for personalized medicine. These advancements are, in part, attributed to the ability of organoid models to stably preserve ge ...
NATURE PORTFOLIO2021The makings of TERRA R-loops at chromosome ends
Joachim Lingner, Marianna Feretzaki, Rita Valador Fernandes
Telomeres protect chromosome ends from nucleolytic degradation, uncontrolled recombination by DNA repair enzymes and checkpoint signaling, and they provide mechanisms for their maintenance by semiconservative DNA replication, telomerase and homologous reco ...
TAYLOR & FRANCIS INC2021Vaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer model
Gabriele Galliverti, Vincent Roh
High-risk human papillomavirus (HPV) encoding E6/E7-HPV oncogenes are responsible for a subgroup of head and neck squamous-cell carcinoma (HNSCC) and thus therapeutic E7-vaccines may be used to control HPV+HNSCC tumors. Herein we investigated the effects o ...
TAYLOR & FRANCIS INC2021High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
Maxim Norkin, Paloma Ordonez Moran
Organoids allow the recapitulation of intestinal homeostasis and cancerogenesis in vitro; however, RNA sequencing (RNA-seq)-based methods for drug screens are missing. We develop targeted organoid sequencing (TORNADO-seq), a high-throughput, high-content d ...
2021Biology and therapeutic targeting of tumour-associated macrophages
Michele De Palma, Tim Beltraminelli
Macrophages sustain tumour progression by facilitating angiogenesis, promoting immunosuppression, and enhancing cancer cell invasion and metastasis. They also modulate tumour response to anti-cancer therapy in pre-clinical models. This knowledge has motiva ...
WILEY2020Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib
Introduction of targeted therapy in the treatment of metastatic cutaneous malignant melanoma (CMM) has improved clinical outcome during the last years. However, only in a subset of the CMM patients, this will lead to long-term effects. CEBPB is a transcrip ...
LIPPINCOTT WILLIAMS & WILKINS2020