Concept
Tissu adipeux
Publications associées (358)
Next Generation Bone Marrow Adiposity Researchers: Report From the 1st BMAS Summer School 2021
The first International Summer School on Bone Marrow Adiposity was organized by members of Bone Marrow Adiposity Society and held virtually on September 6-8 2021. The goal of this meeting was to bring together young scientists interested in learning about ...
FRONTIERS MEDIA SA2022Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity
Hilal Lashuel, Nicolas Jean Philippe Guex, Christian Iseli, Anne-Laure Mahul Mellier, Jonathan Jean-Pierre Ricci, Yllza Jasiqi, Anass Chiki, Sean Michael Deguire, Ritwik Burai, Melek Firat Altay, Salvatore Novello, Sonia Donzelli, Ramanath Narayana Hegde, Pedro José Santana Ribeiro Magalhães
Antibodies against phosphorylated alpha-synuclein (aSyn) at 5129 have emerged as the primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral tissues of patients with Parkinson's disease and other neurodegenerative dis ...
NATURE PORTFOLIO2022Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice
The renin-angiotensin system (RAS) is a key hormonal system. In recent years, the functional analysis of the novel axis of the RAS (ACE2/Ang-(1-7)/Mas receptor) revealed that its activation can become pro-tective against several pathologies, including card ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2022Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34(+) stromal cell subsets
Bart Deplancke, Vincent Roland Julien Gardeux, Julie Marie Russeil, Jörn Pezoldt, Guido Van Mierlo, Maria Litovchenko, Wanze Chen, Marjan Biocanin
Gut-draining mesenteric lymph nodes (LN) provide the framework to shape intestinal adaptive immune responses. Based on the transcriptional signatures established by our previous work, the composition and immunomodulatory function of LN stromal cells (SC) v ...
NATURE PORTFOLIO2022Multiscale light-sheet organoid imaging framework
Petr Strnad, Andrea Boni, Raphaël Ortiz
Live imaging of organoid growth remains a challenge: it requires long-term imaging of several samples simultaneously and dedicated analysis pipelines. Here the authors report an experimental and image processing framework to turn long-term light-sheet imag ...
NATURE PORTFOLIO2022The role and transcriptional regulation of FAM46A in adipocyte differentiation
Obesity is currently a leading global health concern. Treatments include undergoing a weight-loss regimen. However, successful weight-loss is variable, where the heritability of obesity is considered part of the cause. This patient variability to weight-lo ...
EPFL2021Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response
Perturbation of mitochondrial proteostasis provokes cell autonomous and cell non-autonomous responses that contribute to homeostatic adaptation. Here, we demonstrate distinct metabolic effects of hepatic metabokines as cell non-autonomous factors in mice w ...
CELL PRESS2021LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis
Bart Deplancke, Petra Catalina Schwalie
The recruitment of thermogenic brite adipocytes within white adipose tissue attenuates obesity and metabolic comorbidities, arousing interest in understanding the underlying regulatory mechanisms. The molecular network of brite adipogenesis, however, remai ...
WILEY2021Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism
Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Augusto Martins Lima, Maiia Bragina, Léa Liliane Colette Anguenot
Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...
ELSEVIER SCI LTD2021Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity
Kristina Schoonjans, Alessia Perino
Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implic ...
CELL PRESS2021