Publications associées à Tumour heterogeneity

Multiscale homogenization for fluid and drug transport in vascularized malignant tissues

A system of differential equations for coupled fluid and drug transport in vascularized (malignant) tissues is derived by a multiscale expansion. We start from mass and momentum balance equations, stated in the physical domain, geometrically characterized ...

World Scientific Publishing2015

Improving tumor heterogeneity MRI assessment with histograms

Nathalie Just

By definition, tumours are heterogeneous. They are defined by marked differences in cells, microenvironmental factors (oxygenation levels, pH, VEGF, VPF and TGF-α) metabolism, vasculature, structure and function that in turn translate into heterogeneous dr ...

Nature Publishing Group2014

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Application of mild hyperthermia can increase the cytotoxicity of anticancer drugs in tumour cells. In this report, we describe low molecular weight thermoactive ruthenium-based drugs with fluorous chains that are selectively triggered by mild hyperthermia ...

2014

The emerging quest for the optimal angiostatic combination therapy

Patrycja Nowak-Sliwinska, Ume-Gulsoom Abdul

Angiostatic therapies are now routinely embedded in the daily clinical management of cancer. Although these agents clearly benefit patient survival rates, the effect is only moderate with sometimes considerable side effects. A major cause of failure in thi ...

Portland Press Ltd2014

Assessing metastasis risk after pre-operative anti-angiogenic therapy

Michele De Palma, Daniela Biziato

Anti‐angiogenic drugs are approved for the treatment of several cancer types, generally in the inoperable locally advanced or metastatic setting and in combination with other anti‐cancer agents. Recent clinical studies also suggest that anti‐angiogenic dru ...

2014

Low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy for cancer: lack of vascular normalization

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin

Photodynamic therapy (PDT) is an effective clinical treatment for a number of different cancers. PDT can induce hypoxia and inflammation, pro-angiogenic side effects, which may counteract its angio-occlusive mechanism. The combination of PDT with anti-angi ...

2014

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Nadine Fournier, Mauro Delorenzi, Simone Ragusa, Stavros Milatos

The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation. However, the mechanisms of metastatic outgrowth in colorectal cancer remain a major chal ...

Elsevier2014

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

Didier Trono, Priscilla Turelli, Evaristo Jose Planet Letschert, Bastien Mangeat, Marc Samuel Friedli, Adamantia Kapopoulou, Gabriela Ecco, Helen Mary Rowe, Benjamin Rauwel, Carmen Maria Unzu Ezquerro

Endogenous retroelements (EREs) account for about half of the mouse or human genome, and their potential as insertional mutagens and transcriptional perturbators is suppressed by early embryonic epigenetic silencing. Here, we asked how ERE control is maint ...

Cold Spring Harbor Lab Press, Publications Dept2014

Effect of Dispersion Fluctuations on Longitudinal Gain Evolution in Phase-Sensitive Parametric Amplifiers

Luc Thévenaz, Camille Sophie Brès, Marcelo Alfonso Soto Hernandez, Fatemeh Alishahi, Mohammad Amin Shoaie, Andrey Denisov

A Brillouin probing method is proposed to extract the distribution of signal power along phase-sensitive parametric amplifiers. Operation near the zero-dispersion-wavelength shows enhanced sensitivity to dispersion fluctuations, allowing effective extracti ...

2014

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Tumour heterogeneity

Multiscale homogenization for fluid and drug transport in vascularized malignant tissues

Improving tumor heterogeneity MRI assessment with histograms

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

The emerging quest for the optimal angiostatic combination therapy

Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells

Assessing metastasis risk after pre-operative anti-angiogenic therapy

Low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy for cancer: lack of vascular normalization

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

Effect of Dispersion Fluctuations on Longitudinal Gain Evolution in Phase-Sensitive Parametric Amplifiers

Graph Chatbot

Chattez avec Graph Search

Multiscale homogenization for fluid and drug transport in vascularized malignant tissues

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

The emerging quest for the optimal angiostatic combination therapy

Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells

Assessing metastasis risk after pre-operative anti-angiogenic therapy

Effect of Dispersion Fluctuations on Longitudinal Gain Evolution in Phase-Sensitive Parametric Amplifiers

Improving tumor heterogeneity MRI assessment with histograms

Low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy for cancer: lack of vascular normalization