Publications associées à Tumour heterogeneity

Non-Darwinian dynamics in therapy-induced cancer drug resistance

The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastabl ...

Nature Publishing Group2013

The niche under siege: novel targets for metastasis therapy

Albert Santamaria Martinez

Metastasis is an inefficient process and most cancer cells fail to colonize secondary sites. There are several possible reasons for this. First, the nature of the infiltrating cells is important as a small population of cancer stem cells has been shown to ...

Wiley-Blackwell2013

Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy

Julien Racle, Céline Hernández

The molecular chaperone Hsp90-dependent proteome represents a complex protein network of critical biological and medical relevance. Known to associate with proteins with a broad variety of functions termed clients, Hsp90 maintains key essential and oncogen ...

Public Library of Science2013

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Johan Auwerx, Richardus Houtkooper, Ivan Stamenkovic, Michalina Janiszewska

Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. ...

Cold Spring Harbor Lab Press, Publications Dept2012

Interactions between cancer stem cells and their niche govern metastatic colonization

Albert Santamaria Martinez, Ilaria Malanchi, Hans-Anton Lehr

Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successf ...

2012

Diagnostic microchip to assay 3D colony-growth potential of captured circulating tumor cells

Matthias Lütolf, Stefan Kobel, Samy Gobaa

Microfluidic technology has been successfully applied to isolate very rare tumor-derived epithelial cells (circulating tumor cells, CTCs) from blood with relatively high yield and purity, opening up exciting prospects for early detection of cancer. However ...

2012

Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation

Anguraj Sadanandam, Stephan Wullschleger

BACKGROUND: Our earlier reports demonstrated that membrane-bound semaphorin 5A (SEMA5A) is expressed in aggressive pancreatic cancer cells and tumours, and promotes tumour growth and metastasis. In this study, we examine whether (1) pancreatic cancer cells ...

Nature Publishing Group2012

Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model

Hubert van den Bergh, Elodie Debefve, Hans-Anton Lehr

OBJECTIVES: The pre-treatment of tumour neovessels by low-level photodynamic therapy (PDT) improves the distribution of concomitantly administered systemic chemotherapy. The mechanism by which PDT permeabilizes the tumour vessel wall is only partially know ...

Oxford University Press2012

Spot Identification and Quality Control in Cell-Based Microarrays

Michael Bauer, Blaise Calpe

Cell-based microarrays are being increasingly used as a tool for combinatorial and high throughput screening of cellular microenvironments. Analysis of microarrays requires several steps, including microarray imaging, identification of cell spots, quality ...

Amer Chemical Soc2012

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Tumour heterogeneity

Non-Darwinian dynamics in therapy-induced cancer drug resistance

The niche under siege: novel targets for metastasis therapy

Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Interactions between cancer stem cells and their niche govern metastatic colonization

Diagnostic microchip to assay 3D colony-growth potential of captured circulating tumor cells

Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation

Analyzing fluctuations in car-following

Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model

Spot Identification and Quality Control in Cell-Based Microarrays

Graph Chatbot

Chattez avec Graph Search

Interactions between cancer stem cells and their niche govern metastatic colonization

Non-Darwinian dynamics in therapy-induced cancer drug resistance

Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy

Spot Identification and Quality Control in Cell-Based Microarrays

Analyzing fluctuations in car-following

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model

Diagnostic microchip to assay 3D colony-growth potential of captured circulating tumor cells

The niche under siege: novel targets for metastasis therapy

Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation