Concept

Membrane vesicle trafficking

Publications associées (227)

Endosomes: Guardians Against [Ru(Phen)3]2+ Photo-action In Endothelial Cells During In Vivo pO2 Detection?

Phototoxicity is a side-effect of in vitro and in vivo oxygen partial pressure (pO(2)) detection by luminescence lifetime measurement methods. Dichlorotris(1,10-phenanthroline)-ruthenium(II) hydrate (Ru(Phen)(3)) is a water soluble pO(2) probe associ ...

Royal Soc Chemistry2014

Demonstration of suppressed phonon tunneling losses in phononic bandgap shielded membrane resonators for high-Q optomechanics

Luis Guillermo Villanueva Torrijo, Albert Schliesser

Dielectric membranes with exceptional mechanical and optical properties present one of the most promising platforms in quantum optomechanics. The performance of stressed silicon nitride nanomembranes as mechanical resonators notoriously depends on how thei ...

Optical Society of America2014

Refining Mitochondria Segmentation in Electron Microscopy Imagery with Active Surfaces

Pascal Fua, Anne Alison Jorstad

We present an active surface-based method for refining the boundary surfaces of mitochondria segmentation data. We exploit the fact that mitochondria have thick dark membranes, so referencing the image data at the inner membrane can help drive a more accur ...

Springer2014

Insertion of Nanoparticle Clusters into Vesicle Bilayers

Rudolf Hovius, Davide Demurtas, Alke Fink

A major contemporary concern in developing eective liposomeÀnanoparticle hybrids is the present inclusion size limitation of nanoparticles between vesicle bilayers, which is considered to be around 6.5 nm in diameter. In this article, we present experimen ...

Amer Chemical Soc2014

Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

Francesco Stellacci, Paulo Henrique Jacob Silva, Kislon Voitchovsky, Javier Reguera Gomez, Maria Ricci

Recent work has demonstrated that charged gold nanoparticles (AuNPs) protected by an amphiphilic organic monolayer can spontaneously insert into the core of lipid bilayers to minimize the exposure of hydrophobic surface area to water. However, the kinetic ...

Nature Publishing Group2014

Molecular and Dimensional Profiling of Highly Purified Extracellular Vesicles by Fluorescence Fluctuation Spectroscopy

Horst Vogel, Davide Demurtas, Luigino Grasso, Romain Wyss, Camille Wolf, Hans Wolfgang Grosse

Cells secrete extracellular vesicles (EVs) into their microenvironment that act as mediators of intercellulard communication under physiological conditions and in this context also actively participate in spreading various diseases. Large efforts are curre ...

Amer Chemical Soc2014

How Viruses Hijack the ERAD Tuning Machinery

Maurizio Molinari, Riccardo Bernasconi

An essential step during the intracellular life cycle of many positive-strand RNA viruses is the rearrangement of host cell membranes to generate membrane-bound replication platforms. For example, Nidovirales and Flaviviridae subvert the membrane of the en ...

Amer Soc Microbiology2014

An Alien Divalent Ion Reveals a Major Role for Ca2+ Buffering in Controlling Slow Transmitter Release

Ralf Schneggenburger, Daniel Keller, Olexiy Kochubey, Zsolt Norbert Babai

Ca2+-dependent transmitter release occurs in a fast and in a slow phase, but the differential roles of Ca2+ buffers and Ca2+ sensors in shaping release kinetics are still controversial. Replacing extracellular Ca2+ by Sr2+ causes decreased fast release but ...

2014

Full Fabrication and Packaging of an Implantable Multi-panel Device for Monitoring of Metabolites in Small Animals

Giovanni De Micheli, Sandro Carrara, Catherine Dehollain, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Enver Gürhan Kilinç, Daniele Casarino

In this work, we show the realization of a fully-implantable device for monitoring free-moving small animals. The device integrates a microfabricated sensing platform, a coil for power and data transmission and two custom designed integrated circuits. The ...

Ieee-Inst Electrical Electronics Engineers Inc2014

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Stewart Cole, Claudia Sala, Ruben Hartkoorn, Andrej Benjak, Anthony Vocat, Ming Zhang, Jan Lars Rybniker, Jeffrey Chen, Edina Rita Székely

Mycobacterium tuberculosis (Mtb) requires protein secretion systems like ESX-1 for intracellular survival and virulence. The major virulence determinant and ESX-1 substrate, EsxA, arrests phagosome maturation and lyses cell membranes, resulting in tissue d ...

Cell Press2014

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