Concept
Glycéraldéhyde-3-phosphate déshydrogénase
Publications associées (33)
Perfect adaptation achieved by transport limitations governs the inorganic phosphate response in S. cerevisiae
Sebastian Maerkl, Shiyu Cheng, Hon Ming Andrew Yip, Evan James Olson, Michael Andrew Crone
Cells cope with and adapt to ever-changing environmental conditions. Sophisticated regulatory networks allow cells to adjust to these fluctuating environments. One such archetypal system is the Saccharomyces cerevisiae Pho regulon. When external inorganic ...
Washington2023Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors
CAR-T cell therapy has shown remarkable success in treating hematopoietic malignancies, but its efficacy in solid tumors is limited by T cell dysfunction, including exhaustion and senescence. In this study, we designed metabolically armored CAR-T cells to ...
EPFL2023Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization
Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer
Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...
FRONTIERS MEDIA SA2022Proteomics reveals unique plasma signatures in constitutional thinness
Loïc Dayon, Jörg Hager, Nele Gheldof
Purpose Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and dis ...
WILEY-V C H VERLAG GMBH2022Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis
Arnaud Comment, Hikari Ananda Infinity Yoshihara
As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to be measured more routinely. ...
2021The Appearance of the Warburg Effect in the Developing Avian Eye Characterized In Ovo: How Neurogenesis Can Remodel Neuroenergetics
Rolf Gruetter, Carole Poitry-Yamate, Antoine Timothée Cherix, Laurent Brodier
PURPOSE. The avian eye is an established model for exploring mechanisms that coordinate morphogenesis and metabolism during embryonic development. Less is known, however, about trafficking of bioenergetic and metabolic signaling molecules that are involved ...
2020Metabolic rescue of muscle and muscle stem cells in muscle disease
Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...
EPFL2020Pyruvate cellular uptake and enzymatic conversion probed by dissolution DNP-NMR: the impact of overexpressed membrane transporters
Arnaud Comment, Paul Romeo Vasos, Riccardo Balzan
Pyruvate membrane crossing and its lactate dehydrogenase-mediated conversion to lactate in cells featuring different levels of expression of membrane monocarboxylate transporters (MCT4) were probed by dissolution dynamic nuclear polarization-enhanced NMR. ...
Wiley2017Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies
Cristina Ramona Cudalbu, Veronika Rackayová
Creatine (Cr) is an important organic compound acting as intracellular high-energy phosphate shuttle and in energy storage. While located in most cells where it plays its main roles in energy metabolism and cytoprotection, Cr is highly concentrated in musc ...
Elsevier2017