Concept
Circuit topology
Publications associées (14)
Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions
Post-translational modifications (PTMs) play a pivotal role in regulating protein structure, interaction, and function. Aberrant PTM patterns are associated with diseases. Moreover, individual PTMs have a complex interaction with each other, known as PTM c ...
EPFL2024Complex polymer topologies and polymer-nanoparticle hybrid films prepared via surface-initiated controlled radical polymerization
Advances in controlled radical polymerization over the past two decades have transformed the ability to produce molecularly well-defined, chain-end tethered polymer brush films. The assets of controlled radical polymerization reactions have impacted the sy ...
PERGAMON-ELSEVIER SCIENCE LTD2020Phosphoregulated orthogonal signal transduction in mammalian cells
Orthogonal tools for controlling protein function by post-translational modifications open up new possibilities for protein circuit engineering in synthetic biology. Phosphoregulation is a key mechanism of signal processing in all kingdoms of life, but too ...
2020Molecular dissection of amyloid disaggregation by human HSP70
Paolo De Los Rios, Alessandro Barducci
The molecular steps that lead to the disaggregation of amyloid fibrils are shown to involve the synergistic action of HSP70 and its co-chaperones DNAJB1 and HSP110. The deposition of highly ordered fibrillar-type aggregates into inclusion bodies is a hallm ...
NATURE RESEARCH2020Integrally attached timber folded surface structures
In structural engineering, folded surface structures present one of the concepts for construction of self supporting column free systems. They utilize structural benefits of folding to achieve material saving and improve structural efficiency. The folding ...
EPFL2017Molecular Strategies for Morphology Control in Semiconducting Polymers for Optoelectronics
Solution-processable semiconducting polymers have been explored over the last decades for their potential applications in inexpensively fabricated transistors, diodes and photovoltaic cells. However, a remaining challenge in the field is to control the sol ...
Schweizerische Chemische Gesellschaft2017Interplay of Chemical and Electronic Structure on the Single-Molecule Level in 2D Polymerization
Klaus Kern, Claudius Morchutt, Carola Strasser
Single layers of covalently linked organic materials in the form of two-dimensional (2D) polymers constitute structures complementary to inorganic 2D materials. The electronic properties of 2D polymers may be manipulated through a deliberate choice of the ...
American Chemical Society2016Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction
Françoise Gisou van der Goot Grunberg, Jérôme Bürgi
Intrinsically disordered regions (IDRs) are peculiar stretches of amino acids that lack stable conformations in solution. Intrinsic Disorder containing Proteins (IDP) are defined by the presence of at least one large IDR and have been linked to multiple ce ...
Public Library of Science2016Middle-down approaches for mass spectrometry-based protein identification and characterization
Mass spectrometry (MS) has emerged over the last two decades as the analytical technique of choice in systems-level protein studies, known as proteomics. Two are the MS-based approaches generally applied to proteomics: bottom-up (BU), which relies on the p ...
EPFL2016Timber Folded Plate Structures – Folded Form Analysis
Yves Weinand, Christopher Werner Matthias Robeller, Andrea Stitic
This paper analyses the potential of different possible folded form topologies for generating timber folded surface structures. The main advantage of such structures lies primarily in the realm of ecology and sustainability. By offering an integral way of ...
2015