Concept

Enveloppe virale

Publications associées (132)

RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection

A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell factors required during vaccinia virus infection. Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a me ...

Elsevier BV2012

Site-Specific PEGylation of HR2 Peptides: Effects of PEG Conjugation Position and Chain Length on HIV-1 Membrane Fusion Inhibition and Proteolytic Degradation

Harm-Anton Klok, Maarten Danial

Peptides derived from the HR1 or HR2 regions of the HIV-1 envelope glycoprotein gp41 have been shown to be effective inhibitors to prevent virus-host cell membrane fusion. These peptide drugs, however, suffer from relatively short plasma half-lives and are ...

Amer Chemical Soc2012

Three dimensional morphology of rabies virus studied by cryo-electron tomography

Paul Guichard

The rabies virus (RABV) continues to be a worldwide health problem. RABV contains a single-stranded RNA genome that associates with the nucleoprotein N. The resulting ribonucleoprotein complex is surrounded by matrix protein M, lipid bilayer and glycoprote ...

2011

Combating HIV Type 1 with Peptide - Synthetic Polymer Conjugates

Maarten Danial

Polymer therapeutics is a class of (bio)hybrid materials that include a plethora of biologically active (synthetic) macromolecules that either consist of polymeric drugs, drug-polymer conjugates, peptide/protein-polymer conjugates or of drug, peptide or pr ...

EPFL2011

A framework for using quantitative PCR as a non-culture based method to estimate virus infectivity

Tamar Kohn, Martin Ackermann, Brian Pecson

Measuring the efficiency of virus disinfection with quantitative PCR (qPCR) has been criticized as inadequate due to the production of false-positive signals. Such a claim, however, presupposes an understanding of the theoretical qPCR response. Many studie ...

2011

Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages

Jacques Fellay

HIV-1 infected macrophages play an important role in rendering resting T cells permissive for infection, in spreading HIV-1 to T cells, and in the pathogenesis of AIDS dementia. During highly active anti-retroviral treatment (HAART), macrophages keep produ ...

Public Library of Science2011

Estimating the net contribution of IL28B variation to spontaneous hepatitis C virus clearance

Jacques Fellay, Amalio Telenti, Julia di Iulio

The identification of associations between IL28B variants and spontaneous clearance of hepatitis C virus (HCV) raises the issues of causality and of the net contribution of host genetics to the trait. To estimate more precisely the net effect of IL28B gene ...

2011

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

Didier Trono, Pierre Maillard, Olivier Michielin

The tropism of retroviruses relies on their ability to exploit cellular factors for their replication as well as to avoid host-encoded inhibitory activities such as TRIM5α. N-tropic murine leukemia virus is sensitive to human TRIM5α (huTRIM5α) restriction, ...

American Society for Biochemistry and Molecular Biology2010

An Optofluidic Nanoplasmonic Biosensor for Direct Detection of Live Viruses from Biological Media

Hatice Altug, Min Huang

Fast and sensitive virus detection techniques which can be rapidly deployed at multiple sites are essential to prevent and control future epidemics and bioterrorism threats In this Letter we demonstrate a label free optofluidic nanoplasmonic sensor that ca ...

2010

Oxidation of Virus Proteins during UV(254) and Singlet Oxygen Mediated Inactivation

Tamar Kohn, Jonathan Paz Montoya, Krista Rule Wigginton

Despite the widespread use of UV254 irradiation and solar disinfection for water treatment, little is known about the photochemical pathways that lead to virus inactivation by these treatments. The goal of this study was to identify reactions that occur in ...

2010

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