Publications associées à Vertèbre

Fatigue behavior of transverse attachments under constant and variable amplitude loading from a Swiss motorway bridge

Alain Nussbaumer, Davide Leonetti, Yukina Takai

This paper investigates the fatigue behavior of non-load-carrying transverse welded steel attachments by reporting on an experimental characterization under constant and variable amplitude loading. Fatigue cracks have been monitored using DIC and ACPD tech ...

Elsevier Sci Ltd2023

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Digital reconstruction of the mammalian spinal cord: from anatomical reference volume to cell type atlas of the mouse spinal cord

Ihor Kuras

The spinal cord is an elongated nervous structure that together with the brain forms the central nervous system. It relays sensory and motor information between the brain and the body, thus controlling most somatic and autonomic body functions. In recent y ...

EPFL2023

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Grégoire Courtine, Quentin Barraud, Lili Huang, Xiaomeng Zhang

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments ...

2021

Lumbar and thoracic kinematics during step-up: Comparison of three-dimensional angles between patients with chronic low back pain and asymptomatic individuals

Julien Favre, Brigitte Jolles-Haeberli, Guillaume Christe

While alterations in spinal kinematics have been repeatedly observed in patients with chronic low back pain (CLBP), their exact nature is still unknown. Specifically, there is a need for comprehensive assessments of multisegment spinal angles during daily- ...

2020

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

Dominique Pioletti, Azadeh Khoushabi, Pierre-Etienne Bourban, Baris Çaglar, Céline Samira Wyss

One of the novel approaches for discogenic lower back pain treatment is to permanently replace the core of the intervertebral disc, so-called Nucleus Pulposus, through minimally invasive surgery. Recently, we have proposed Poly(Ethylene Glycol) Dimethacryl ...

2018

The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice

Susanne Petra Pfeifer

Understanding both the role of selection in driving phenotypic change and its underlying genetic basis remain major challenges in evolutionary biology. Here, we use modern tools to revisit a classic system of local adaptation in the North American deer mou ...

Wiley2017

Chronic low back pain patients walk with locally altered spinal kinematics

Julien Favre, Brigitte Jolles-Haeberli, Guillaume Christe

Various studies have reported alterations of spinal kinematics in patients with chronic low back pain (CLBP) during gait. However, while recent findings stressed the importance of multi-segment analysis, most of prior gait studies modelled the lumbar spine ...

Elsevier Sci Ltd2017

Multi-segment analysis of spinal kinematics during sit-to-stand in patients with chronic low back pain

Julien Favre, Thomas Legrand, Guillaume Christe

While alterations in spinal kinematics have been frequently reported in patients with chronic low back pain (CLBP), a better characterization of the kinematics during functional activities is needed to improve our understanding and therapeutic solutions fo ...

Elsevier Sci Ltd2016

Surgical probe and implant development for nucleus pulposus replacements

Andreas Schmocker

Intervertebral disc degeneration is a major reason why we experience low back pain. Intervertebral discs are located in-between the vertebrae of the spine. They act, among other, as shock absorbers by distributing the mechanical load applied to the spine w ...

EPFL2016