Publications associées à Ménopause prématurée

Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?

Lobular carcinoma represent the most common special histological subtype of breast cancer, with the majority classed as hormone receptor positive. Rates of invasive lobular carcinoma in postmenopausal women have been seen to increase globally, while other ...

Endocrine Soc2024

Socioeconomic development predicts a weaker contraceptive effect of breastfeeding

Mathias Lerch

The contraceptive effect of breastfeeding remains essential to controlling fertility in many developing regions of the world. The extent to which this negative effect of breastfeeding on ovarian activity is sensitive to ecological conditions, notably mater ...

National Academy of Sciences2021

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

Benjamin Dieter Weger, Meltem Weger

Background: Deficient glucocorticoid biosynthesis leading to adrenal insufficiency is life-threatening and is associated with significant co-morbidities. The affected pathways underlying the pathophysiology of co-morbidities due to glucocorticoid deficienc ...

2018

Water soluble derivatives of platinum carbonyl Chini clusters: synthesis, molecular structures and cytotoxicity of [Pt-12(CO)(20)(PTA)(4)](2-) and [Pt-15(CO)(25)(PTA)(5)](2-)

Paul Joseph Dyson, Lucinda Kate Batchelor, Silvia Ruggieri

The reactions of Pt-3n(CO)(6n) (n = 2-5) homoleptic Chini-type clusters with increasing amounts of 1,3,5-triaza-7-phosphaadamantane (PTA) result in the stepwise substitution of one terminal CO ligand per Pt-3 triangular unit up to the formation of [P ...

2018

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Cathrin Brisken, Kathryn Hess Bellwald, Rachel Marcone

Worldwide, breast cancer incidence has been increasing for decades. Exposure to reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk, and can promote disease progression. Exogenous hormones and endocrine disruptors h ...

2015

Culture of preantral follicles in poly(ethylene) glycol-based, three-dimensional hydrogel: a relationship between swelling ratio and follicular developments

Jeffrey Alan Hubbell, Seung Tae Lee

This study was undertaken to examine how the softness of poly(ethylene) glycol (PEG)-based hydrogels, creating a three-dimensional (3D) microenvironment, influences the in vitro growth of mouse ovarian follicles. Early secondary, preantral follicles of 2we ...

Wiley-Blackwell2015

Highly water soluble trithiolato-bridged dinuclear arene ruthenium complexes

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Noelia Claude Herrero

Water soluble arene-functionalised trithiolato-bridged ruthenium complexes of general formula (eta(6)-C6H5OCH2CH2OH)(2)Ru-2(mu-SR)(3), where R = C6H5 (1), C6H4-p-OMe (2), C6H4-p-OMe (3), C6H4-p-Pr-i (4), C6H4-p-Bu-t (5), CH2C6H5 (6), CH2CH2C6H5 (7) an ...

Elsevier Science Sa2014

Liver receptor homolog-1 is essential for pregnancy

Kristina Schoonjans

Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis(1). It is strongly expres ...

Nature Publishing Group2013

Cyclin D1 Enhances the Response to Estrogen and Progesterone by Regulating Progesterone Receptor Expression

Cathrin Brisken

Estrogen and progesterone are the defining hormones of normal female development, and both play critical roles in breast carcinogenesis. Cyclin D1 is a breast cancer oncogene whose amplification is linked to poor prognosis in estrogen and progesterone rece ...

American Society for Microbiology2010