Concept
Fécondation
Publications associées (37)
Extensive programmed centriole elimination unveiled in C. elegans embryos
Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...
AMER ASSOC ADVANCEMENT SCIENCE2023Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
Pierre Gönczy, Fernando Romero Balestra
Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the ...
GENETICS SOCIETY AMERICA2023Centriole foci persist in starfish oocytes despite Polo-like kinase 1 inactivation or loss of microtubule nucleation activity
Pierre Gönczy, Nils Kalbfuss, Marie Juliette Ségolène Pierron
Centrioles must be eliminated or inactivated from the oocyte to ensure that only the two functional centrioles contributed by the sperm are present in the zygote. Such removal can occur during oogenesis, as in Drosophila, where departure of Polo kinase fro ...
2020