Concept

Extended evolutionary synthesis

Publications associées (80)

Deoxygenative Transformation of Alcohols via Phosphoranyl Radical from Exogenous Radical Addition

A general approach to the direct deoxygenative transformation of primary, secondary, and tertiary alcohols has been developed. It undergoes through phosphoranyl radical intermediates generated by the addition of exogenous iodine radical to trivalent alkoxy ...

Weinheim2024

VolRecon: Volume Rendering of Signed Ray Distance Functions for Generalizable Multi-View Reconstruction

Sabine Süsstrunk, Tong Zhang, Yufan Ren

The success of the Neural Radiance Fields (NeRF) in novel view synthesis has inspired researchers to propose neural implicit scene reconstruction. However, most existing neural implicit reconstruction methods optimize perscene parameters and therefore lack ...

2024

Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks

Florence Gauye, Florian Baier

Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis con-founds our understanding of how mutations affect the expression patterns of gene regulatory networks, a chal-lenge exacerbated by the dependence of ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Denis Duboule, Lucille Delisle, Alexandre Gauthier Aurèle Mayran, Hocine Rekaik, Aurélie Hintermann, Célia Corinne Renée Bochaton

Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...

NATURE PORTFOLIO2023

Synthesis and Applications of Ynimines and Enantioselective Total Synthesis of Artatrovirenol A

Rémi Hugo Lavernhe

The first chapter of this thesis describe the development of a general synthesis of ynimines, an under-exploited motif in organic chemistry. In the presence of an inexpensive copper catalyst and 2,2'-biquinoline, reaction of easily accessible O-acyloximes ...

EPFL2023

Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates

Freddy Radtke, Ute Koch, Catherine Michelle Hoffman

Notch signaling promotes T cell pathogenicity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the Delta-like Notch ligand DLL4. To assess whether Notch's effects are evol ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Linguistic traits as heritable units? Spatial Bayesian clustering reveals Swiss German dialect regions

Stéphane Joost, Noemi Romano

In the early 2000s, the SADS, an extensive linguistic atlas project, surveyed more than three thousand individuals across German-speaking Switzerland on over two hundred linguistic variants, capturing the morphosyntactic variation in Swiss German. In this ...

2022

Scene Decomposition and Relighting from Image Collections in Neural Rendering

Dongqing Wang

The focus of our research is to generate controllable photo-realistic images of real-world scenes from existing observations, i.e., the inverse rendering problem. The approaches we focus on are those through neural rendering, utilizing neural network to de ...

2022

The population genetics of crypsis in vertebrates: recent insights from mice, hares, and lizards

Jeffrey David Jensen, Susanne Petra Pfeifer, Stefan Jean Laurent

By combining well-established population genetic theory with high-throughput sequencing data from natural populations, major strides have recently been made in understanding how, why, and when vertebrate populations evolve crypsis. Here, we focus on backgr ...

NATURE PUBLISHING GROUP2020

Linking micro and macroevolution in the presence of migration

Sophie Myriam Hautphenne, Laurent Lehmann, Nicolas Salamin

Understanding macroevolutionary patterns is central to evolutionary biology. This involves the process of divergence within a species, which starts at the microevolutionary level, for instance, when two sub populations evolve towards different phenotypic o ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2020

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