Concept
Biosenseur
Publications associées (32)
Achieving high hybridization density at DNA biosensor surfaces using branched spacer and click chemistry
Sandrine Gerber, Mounir Driss Mensi, Alireza Kavand, Perrine Agnes Edith Robin, Lucas Mayoraz
The COVID-19 pandemic has highlighted the necessity to develop fast, highly sensitive and selective virus detection methods. Surface-based DNA-biosensors are interesting candidates for this purpose. Functionalization of solid substrates with DNA must be pr ...
2023Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain
Stéphanie Lacour, John Martin Kolinski, Outman Akouissi, Michael Shur, Olivier Didier Christian Rizzo
The brain is an ultra-soft viscoelastic matrix. Sub-kPa hydrogels match the brain's mechanical properties but are challenging to manipulate in an implantable format. We propose a simple fabrication and processing sequence, consisting of de-hydration, patte ...
2023Simultaneous local sensing of two chemical properties with dual soft probe scanning electrochemical microscopy
Hubert Girault, Andreas Stephan Lesch, Gregorio Bonazza
A new method for the rapid and economic fabrication of dual soft microelectrodes for Soft-Probe-Scanning electrochemical microscopy (Soft-Probe-SECM) and their use for the simultaneous local detection of locally generated species is presented. The process ...
PERGAMON-ELSEVIER SCIENCE LTD2023Stabilizing Polymer Coatings Alter the Protein Corona of DNA Origami and Can Be Engineered to Bias the Cellular Uptake
Maartje Martina Cornelia Bastings, Hugo José Rodriguez Franco, Jorieke Weiden
With DNA-based nanomaterials being designed for applicationsincellular environments, the need arises to accurately understand theirsurface interactions toward biological targets. As for any materialexposed to protein-rich cell culture conditions, a protein ...
AMER CHEMICAL SOC2023Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling
Felix Naef, Nicholas Edward Phillips
Wearable biosensors and smartphone applications can measure physiological variables over multiple days in free-living conditions. We measure food and drink ingestion, glucose dynamics, physical activity, heart rate (HR), and heart rate variability (HRV) in ...
CELL PRESS2023Review on Uric Acid Recognition by MOFs with a Future in Machine Learning
Uric acid (UA) is produced from purine metabolism and serves as a prevalent biomarker for multiple diseases including cancer. Hyperuricemia or hypouricemia can cause multiple dysfunctions throughout the biological processes. Consequently, there is a pressi ...
Washington2023Theoretical analysis of divalent cation effects on aptamer recognition of neurotransmitter targets
Nako Nakatsuka, Dmitry Momotenko, Annina Stuber
Aptamer-based sensing of small molecules such as dopamine and serotonin in the brain, requires characterization of the specific aptamer sequences in solutions mimicking the in vivo environment with physiological ionic concentrations. In particular, divalen ...
2023Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis
Patrick Daniel Barth, Aurélien Laurent Jean-Charles Oggier, Ana Paola Rico Villarreal, Mahdi Hijazi, Robert Everett Jefferson, Andreas Füglistaler
Engineering protein biosensors that sensitively respond to specific biomolecules by triggering precise cellular responses is a major goal of diagnostics and synthetic cell biology. Previous biosensor designs have largely relied on binding structurally well ...
2023Dendrimer-Based Coatings on a Photonic Crystal Surface for Ultra-Sensitive Small Molecule Detection
We propose and demonstrate dendrimer-based coatings for a sensitive biochip surface that enhance the high-performance sorption of small molecules (i.e., biomolecules with low molecular weights) and the sensitivity of a label-free, real-time photonic crysta ...
MDPI2023