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The limitations and potential complications correlated with autogenous bone grafts have raised interest in the development of synthetic bone graft substitutes. ß-tricalcium phosphate (ß-TCP) is one of the most promising materials for synthetic bone graft s ...
Cell therapy could be a solution for many diseases that currently pose a huge health burden on patients. Especially, cell therapies based on cell microencapsulation are of great interest. Immunoprotection of cells would allow to avoid the need for immunosu ...
Periodontitis is a common chronic inflammatory disease that affects tooth-supporting tissues. We engineer a multifunctional periodontal membrane for the guided tissue regeneration of lost periodontal tissues. The major drawback of current periodontal membr ...
This Master’s project entitled ’Quantifying Bacterial Structure of Aerobic Granular Sludge using Image Analysis’ aims to quantitatively describe various aspects of cell activity inside aerobic granular sludge using image analysis. It entails the theory of ...
We present a dielectric elastomer actuator (DEA) for in vitro analysis of mm2 biological samples under periodic compressive stress. Understanding how mechanical stimuli affect cell functions could lead to significant advances in diseases diagnosis and drug ...
This thesis advances the field of dielectric elastomer actuators (DEAs) through the development of device designs, fabrication processes, strain characterization technique and modelling tool. It provides the first demonstration that DEAs can be interfaced ...
Bone fracture healing problems, because of the loss of tissue regeneration, can affect many old or multi-pathologic patients around the world. Among the therapeutic strategies, bone substitutes, such as poly-(L-lactitve acid) with 5% wt. % ß-tricalcium pho ...
Tissues morphogenesis and homeostasis involve the spatiotemporal regulation of mechanics at multiple scales. Characterization of mechanical properties of biological systems as well as investigating the effects of mechanical forces on biological function ar ...
The recapitulation of tissue organization and function in vitro is one of the main objectives of tissue engineering. Proper tissue function depends on the spatial assembly and interactions between key components such as cells, growth factors, signaling cue ...
In native tissues, the interaction between cells and the surrounding extracellular matrix (ECM) is reciprocal, as cells not only receive signals from the ECM but also actively remodel it through secretion of cell-derived ECM. However, very little is known ...