Concept

Chimioprotéomique

Publications associées (92)

Drug concentration prediction and delivery

Giovanni De Micheli, Alena Simalatsar, Wenqi You Dubout

In medical practice, the decision-making process regarding drug dose is critical to patients’ health and recovery. For drugs with narrow therapeutic ranges, the medical doctor decides the quantity (dose amount) and frequency (dose interval) on the basis of ...

2014

Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries

Christian Heinis, Petr Leiman, Shiyu Chen, Jeremy Touati, Julia Morales Sanfrutos

Bicyclic peptide ligands were found to have good binding affinity and target specificity. However, the method applied to generate bicyclic ligands based on phage-peptide alkylation is technically complex and limits its application to specialized laboratori ...

2013

Synthesis and characterization of a new class of anti-angiogenic agent based on ruthenium clusters

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Mathurin Baquié

New triruthenium-carbonyl clusters derivatized with glucose-modified bicyclophosphite ligands have been synthesized. These compounds were found to have cytostatic and cytotoxic activity and depending on the number of bicyclophosphite ligands, and could be ...

2013

Proteome Digestion Specificity Analysis for Rational Design of Extended Bottom-up and Middle-down Proteomics Experiments

Yury Tsybin, Kristina Srzentic, Unige Anna Laskay

Mass spectrometry (MS)-based bottom-up proteomics (BUP) is currently the method of choice for large-scale identification and characterization of proteins present in complex samples, such as cell lysates, body fluids, or tissues. Technically, BUP relies on ...

Amer Chemical Soc2013

Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets

Kai Johnsson, Simone Moser

Mycobacterium goes yeast: Target deconvolution of anti-tuberculosis drugs can be a very challenging task. Here we report a yeast 3-hybrid system that allows promising small molecules to be screened for protein targets of a pathogen in nontoxic yeast cells. ...

Wiley-V C H Verlag Gmbh2013

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

Matthias Lütolf, Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Adrian Ranga

By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...

National Academy of Sciences2013

Morphological investigation of polylactide/microfibrillated cellulose composites

Pierre-Etienne Bourban, John Christopher Plummer, Carole Boissard

Optical microscopy and transmission electron microscopy have been used to investigate the morphology of polylactide (PLA)/microfibrillated cellulose (MFC) composites prepared by: compression molding of wet-comingled MFC and PLA latex or powder, twin-screw ...

Springer Berlin Heidelberg2013

Probing Odorant-Mediated Receptor Activation

Olivia Baud

Molecular interactions of odorants with their olfactory receptors (ORs) are of central importance for the mammalian olfactory system to detect and discriminate a large variety of odors with a limited set of receptors. How a particular OR binds and distingu ...

EPFL2012

Block copolymer-directed assembly of bare metal oxide nanocrystals for energy-related devices

Raffaella Buonsanti

The properties of metal oxide nanocrystals in energy-related devices are strongly dependent on the presence and chem. nature of ligands at their surface, and the architectures they assume in electroactive layers. The article presents a comprehensive strate ...

2012

Polyvalent Side Chain Peptide-Synthetic Polymer Conjugates as HIV-1 Entry Inhibitors

Harm-Anton Klok, Maarten Danial

This report describes the synthesis and properties of a series of polyvalent side chain peptide synthetic polymer conjugates designed to block the CD4 binding site on gp120 and inhibit HIV-1 entry into a host cell. The peptide sequences in the conjugates a ...

2012

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