Concept

Immunoglobuline G

Publications associées (67)

Antibodies and IL-3 support helminth-induced basophil expansion

Nicola Harris, Mario Michael Zaiss, Manuel Kulagin, Tina Herbst

Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknow ...

Natl Acad Sciences2012

Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides

Lorène Aeschbach, Patrick Fraering, Tristan Bolmont, Jemila Houacine

The toxic amyloid-β (Aβ) peptides involved in Alzheimer's disease (AD) are produced after processing of the amyloid precursor protein-C-terminal fragment APP-C99 by γ-secretase. Thus, major therapeutic efforts have been focused on inhibiting the activity o ...

Elsevier Science Inc2012

Comparison of printed glycan array, suspension array and ELISA in the detection of human anti-glycan antibodies

Darlene Goldstein

Anti-glycan antibodies represent a vast and yet insufficiently investigated subpopulation of naturally occurring and adaptive antibodies in humans. Recently, a variety of glycan-based microarrays emerged, allowing high-throughput profiling of a large reper ...

2011

Engineering Erythrocyte Affinity for Improved Pharmacokinetics and Immune Tolerogenesis

Stephane Kontos

The clinical success of recombinant protein therapeutics in the treatment of disease is a hallmark of modern medical research, yet there remain numerous unaddressed issues regarding their delivery and immunogenicity. Regardless of in vivo efficacy, the bio ...

EPFL2011

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity

Nicola Harris

Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases. However, Kit mutations affect multiple cell types of both immune and n ...

Elsevier2011

Transduction of Glycan-Lectin Binding Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Glycan Profiling

Ardemis Anoush Boghossian

There is significant interest in developing new detection platforms for characterizing glycosylated proteins, despite the lack of easily synthesized model glycans or high affinity receptors for this anal. problem. In this work, the authors demonstrate a se ...

2011

Valproic acid enhances recombinant mRNA and protein levels in transiently transfected Chinese hamster ovary cells

Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Sarah Wulhfard

Valproic acid (VPA) is a small molecule that inhibits histone deacetylase activity. Here we report that VPA increases recombinant mRNA and protein levels in transiently transfected CHO DG44 cells. In the presence of VPA, transient recombinant antibody yiel ...

Elsevier2010

FcRgamma activation regulates inflammation-associated squamous carcinogenesis

Michele De Palma, Ferdinando Pucci

Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mo ...

2010

Increasing the efficiency of lanthanide luminescent bioprobes: bioconjugated silica nanoparticles as markers for cancerous cells

Anne-Sophie Chauvin, Caroline Vandevyver, Svetlana Eliseeva, Bo Song, Josias Basil Wacker

The lanthanide binuclear helicate [Ln(2)(L-C2)(3)] has been embedded into bare and NH2-functionalized silica nanoparticles (NPs) using water-in-oil microemulsion technique. TEM analysis reveals both [Ln(2)(L-C2)(3)]@SiO2 and [Ln(2)(L-C2)(3)]@SiO2/NH2 nanop ...

Royal Society of Chemistry2010

Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer's mouse model

Osiris Marroquin Belaunzaran

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly population. AD currently affects approximately 27 million people worldwide. A pathological hallmark of AD is the accumulation and deposition of the amyloid beta (Aβ) pe ...

EPFL2009

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