Concept

Pathophysiology of multiple sclerosis

Publications associées (21)

Astrocyte scar formation aids central nervous system axon regeneration

Mark Andrew Anderson, Michael V. Sofroniew

Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte sca ...

Nature Publishing Group2016

Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury

Yohan Van de Looij

Cerebral white and grey matter injury is the leading cause of an adverse neurodevelopmental outcome in prematurely born infants. High oxygen concentrations have been shown to contribute to the pathogenesis of neonatal brain damage. Here, we focused on moto ...

Hindawi Limited2016

Quantitative Susceptibility Mapping in the Human Brain

Diana Khabipova

Magnetic resonance imaging (MRI) offers a good tissue contrast and the ability to visualize many disease related morphologies. The work presented in this thesis investigates the study of underlying structure of the brain using quantitative methods with a s ...

EPFL2016

Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia

Yohan Van de Looij

Cerebral white matter injury is a leading cause of adverse neurodevelopmental outcome in prematurely born infants involving cognitive deficits in later life. Despite increasing knowledge about the pathophysiology of perinatal brain injury, therapeutic opti ...

Elsevier2016

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Rolf Gruetter, Cristina Ramona Cudalbu

A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectrosc ...

2014

Migraineurs without aura show microstructural abnormalities in the cerebellum and frontal lobe

David Paul Roger Romascano, Alessandro Daducci, Cristina Granziera, Nouchine Hadjikhani, Gunnar Krüger, Alexis Roche

The involvement of the cerebellum in migraine pathophysiology is not well understood. We used a biparametric approach at high-field MRI (3 T) to assess the structural integrity of the cerebellum in 15 migraineurs with aura (MWA), 23 migraineurs without aur ...

Springer US2013

In-vivo single neuron axotomy triggers axon regeneration to restore synaptic density in specific cortical circuits

Graham Knott, Bohumil Maco

To what extent, how and when axons respond to injury in the highly interconnected grey matter is poorly understood. Here we use two-photon imaging and focused ion beam-scanning electron microscopy to explore, at synaptic resolution, the regrowth capacity o ...

2013

Characterisation of Living Matter Using Advanced Spectroscopy Techniques

Markus Bonda

In the context of an ageing society neurodegenerative disease have become more and more frequent among humans. Opposing the benefits of a longer life, these diseases have thus triggered research on neurons and how they interact with each other. In vitro as ...

EPFL2011

Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model

Patrick Aebischer, Jean-Charles Bensadoun

X-linked adrenoleukodystrophy (X-ALD) is the most common inherited peroxisomal disorder characterized by a progressive demyelination of the central nervous system. The marked loss of myelin and oligodendrocytes observed in the disease prompted us to evalua ...

2009

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity

Freddy Radtke

Notch signaling is central to vertebrate development, and analysis of Notch has provided important insights into pathogenetic mechanisms in the CNS and many other tissues. However, surprisingly little is known about the role of Notch in the development and ...

2009

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