Concept
Hépatocyte
Publications associées (42)
Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes
In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. This study invest ...
WILEY-V C H VERLAG GMBH2022Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
Bart Deplancke, Wouter Saelens
The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of the healthy and obese human and murine liver combining single-cell CITEseq, single-nuclei sequencing, spatial tran ...
CELL PRESS2022Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice
Kristina Schoonjans, Adriano Maida
The bile acid receptor, TGR5, is a key regulator of glucose homeostasis, but the mechanisms by which TGR5 signaling improves glucose regulation are incompletely defined. In particular, TGR5 has an increasingly appreciated role in liver physiology and patho ...
2020Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates
Kei Sakamoto, Maria Deak, Caterina Collodet, Susanne Seitz
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug target for treatment of medical conditions particularly associated with me ...
ELSEVIER SCIENCE INC2019Beneficial effects of Human Mesenchymal Stromal Cells on Porcine Hepatocyte Viability and Albumin Secretion
Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Luca Szabó, Aurélien Thomas
Porcine hepatocytes transplanted during acute liver failure might support metabolic functions until the diseased liver recovers its function. Here, we isolated high numbers of viable pig hepatocytes and evaluated hepatocyte functionality after encapsulatio ...
2018