Concept

Compartiment cellulaire

Publications associées (144)

Fluorescent Nanodiamond–Gold Hybrid Particles for Multimodal Optical and Electron Microscopy Cellular Imaging

There is a continuous demand for imaging probes offering excellent performance in various microscopy techniques for comprehensive investigations. of cellular processes by more than, one technique. FluoreScent nanodianiond gold nanoparticles (END Au) consti ...

Amer Chemical Soc2016

Influence of Block versus Random Monomer Distribution on the Cellular Uptake of Hydrophilic Copolymers

Harm-Anton Klok, John Moraes, Muriel Blum, Raoul Peltier

The use of polymers has revolutionized the field of drug delivery in the past two decades. Properties such as polymer size, charge, hydrophilicity, or branching have all been shown to play an important role in the cellular internalization of polymeric syst ...

2016

GOLPH3 and oncogenesis: What is the molecular link?

Riccardo Rizzo

The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainl ...

2016

Monitoring the Cellular Cholesterol Distribution via NanoSIMS Imaging

Mustafa Demir

Cholesterol is a very crucial lipid for animal cells, since it is the building block of cellular membranes, control fluidity of membranes, regulate intracellular transport, cell signalling, nerve conduction and serve as a precursor for synthesis of vitamin ...

2015

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

Carl Petersen, Graham Knott, Natalya Korogod

Analysis of brain ultrastructure using electron microscopy typically relies on chemical fixation. However, this is known to cause significant tissue distortion including a reduction in the extracellular space. Cryo fixation is thought to give a truer repre ...

Elife Sciences Publications Ltd2015

Monitoring the Cellular Cholesterol Distribution via nanoSIMS Imaging

Mustafa Demir

Cholesterol is a very important lipid, manufactured by all animal cells for their use. About 20-25% of total daily cholesterol production occurs in the liver; other sites that have higher synthesis rate are intestine, adrenal glands and reproductive organs ...

2015

Yersinia enterocolitica type III secretion injectisomes form regularly spaced clusters, which incorporate new machines upon activation

Henning Paul-Julius Stahlberg

Bacterial type III secretion systems or injectisomes are multiprotein complexes directly transporting bacterial effector proteins into eukaryotic host cells. To investigate the distribution of injectisomes in the bacterium and the influence of activation o ...

Wiley-Blackwell2015

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

Jeffrey Alan Hubbell, Daniela Sofia Dias Ferreira, Yi-An Lin

The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a proteo ...

Wiley-Blackwell2015

A hybrid computational model to predict chemotactic guidance of growth cones

Silvestro Micera

The overall strategy used by growing axons to find their correct paths during the nervous system development is not yet completely understood. Indeed, some emergent and counterintuitive phenomena were recently described during axon pathfinding in presence ...

Nature Publishing Group2015

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

Françoise Gisou van der Goot Grunberg

The endoplasmic reticulum (ER) forms functional contacts with several cellular organelles and regulates processes such as mitochondrial fission. In a recent issue of Cell, Rowland et al. (2014) extend these findings to endosomes, showing that the ER contac ...

2014

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