Concept

Antithrombine

Publications associées (32)

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Molecular variant fibrinogen fusion proteins

Jeffrey Alan Hubbell, Thomas Barker

Fibrinogen fusion proteins, methods of making, and methods of using fibrinogen fusion proteins are described. In a preferred embodiment the fibrinogen fusion protein contains a truncated Aa chain of fibrinogen. The Aa chain contains truncation site, which ...

2007

Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids

Jeffrey Alan Hubbell

The application describes ligands for binding targets, the ligands preferably including peptides having at least one sulfated or sulfonated amino acid. The ligand preferably specifically binds to heparin binding sites of biomolecules. Compositions, systems ...

2006

Induction of plasminogen activator inhibitor I by the PPARalpha ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway

Johan Auwerx

Impairment of the fibrinolytic system, mostly due to elevated plasma levels of plasminogen activator inhibitor 1 (PAI-1), is often associated with metabolic disorders such as diabetes mellitus and insulin-resistance syndrome. Moreover, insulin, as we have ...

2003

Nuclear localization of mouse fibroblast growth factor 2 requires N-terminal and C-terminal sequences

Friedrich Beermann

In vertebrates, different isoforms of fibroblast growth factor 2 (FGF2) exist, which differ by their N-terminal extension. They show different localization and expression levels and exert distinct biological effects. Nevertheless, genetic inactivation of a ...

2003

The goal of this work was to develop a growth factor delivery system for use in nerve regeneration that would provide localized release of beta-nerve growth factor (b-NGF) and other members of the neurotrophin family in a controlled manner. Although b-NGF ...

2000

Development of fibrin derivatives for controlled release of heparin-binding growth factors

Jeffrey Alan Hubbell

The goal of this work was to develop a growth factor delivery system for use in wound healing that would provide localized release of heparin-binding growth factors in a biomimetic manner, such that release occurs primarily in response to cell-assocd. enzy ...

2000

The goal of this work was to improve the potential of fibrin to promote nerve regeneration by enzymatically incorporating exogenous neurite-promoting heparin-binding peptides. The effects on neurite extension of four different heparin-binding peptides, der ...

1999

5a-carba-beta-D-, 5a-carba-beta-L- and 5-thio-beta-L-xylopyranosides as new orally active venous antithrombotic agents

Pierre Vogel

Mitsunobu displacement of (-)-(1S,4R,5S,6S) -4,5,6-tris{[(tert-butyl)dimethylsilyl] oxy}cyclohex-2-en-1-ol ((-)-12; a (-)-conduritol-F derivative) with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one (16) provided a 5a-carba-beta-D-pyranoside (+)-17 that was conve ...

1998

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

Hilal Lashuel

Insoluble protein fibrils resulting from the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer's disease, familial amyloid polyneuropathy, and senile systemic ...

National Academy of Sciences1998

A slow clearing, fibrin-specific, PAI-1 resistant variant of t-PA (T103N, KHRR 296-299 AAAA)

Florian Maria Wurm

Site directed mutagenesis was used to construct a t-PA variant that contains an additional glycosylation site in the first kringle domain (T103N) combined with a tetra-alanine substitution in the protease domain (KHRR 296-299 AAAA). This combination varian ...

1993