Publications associées à Dyslipidémie

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

Jacques Fellay, Christian Axel Wandall Thorball, Stéphane Fournier, Roxane De La Harpe

Lay Summary The aim of this study is to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores currently recommended by European and US guidelines on cardiovas ...

OXFORD UNIV PRESS2023

Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis

Christopher Tadhg James Wall

Mitochondrial diseases are rare and severe conditions with debilitating symptoms. Biochemical defects in mitochondria however are common. The difference between these two frequencies is suspected to lie in the capability of the cells to adapt to the homeos ...

EPFL2022

The Exchangeable Apolipoprotein Nplp2 Sustains Lipid Flow and Heat Acclimation in Drosophila

Bruno Lemaitre, Jean Philippe Boquete, Samuel Rommelaere, Jérémie Piton

In ectotherms, increased ambient temperature requires the organism to consume substantial amounts of energy to sustain a higher metabolic rate, prevent cellular damage, and respond to heat stress. Here, we identify a heat-inducible apolipoprotein required ...

2019

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

Lilia Noriega Lopez, Laura Alejandra Velazquez Villegas

White adipose tissue (WAT) can differentiate into beige adipose tissue by the browning process. Some polyphenols, including isoflavones, particularly genistein, are suggested to increase the expression of browning markers. There is evidence that consumptio ...

ELSEVIER SCIENCE INC2019

Associations between Daily Walking and Subclinical Health Markers in a Swiss City

Vincent Kaufmann, Emmanuel Pierre Jean Ravalet, Derek Pierre Christie, Idris Guessous

Every year, the Health Bus (Bus Santé) enables a representative sample of around 1000 members of the non-institutionalised adult population of Geneva, Switzerland, to undergo a health evaluation including physical measurements, blood tests and questionnair ...

2017

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Maiia Bragina, Fabiana Pereira Da Costa Fraga

Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Aug 11 and forms Ang-(1-7), has been suggested as a target against ...

Elsevier2015

Impact of hepatic lipid accumulation and composition on glucose tolerance and insulin sensitivity: a longitudinal study in male and female mice

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Background and aims: Metabolic disruptions characterized by high hepatic lipid content (HLC) are associated with impairments in whole body glucose homeostasis. To gain insight on the role of hepatic lipids in the metabolic performance in the absence artifi ...

Springer2014

Insights into the antiatherogenic molecular mechanisms of andrographolide against Porphyromonas gingivalis-induced atherosclerosis in rabbits

Amer Ashrafi

Atherosclerosis is the commonest and most important vascular disease. Andrographolide (AND) is the main bioactive component of the medicinal plant Andrographis paniculata and is used in traditional medicine. This study was aimed to evaluate the antiatherog ...

Springer2014

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Vera Monica Lemos Da Silva, Xu Wang, Chikage Mataki, Pan Xu, Keir Joe Menzies, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014

Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes

Daniel Constam

The proprotein convertases (PCs) furin, PC5/6, and PACE4 exhibit unique and/or complementary functions. Their knockout (KO) in mice resulted in strong and specific phenotypes demonstrating that, in vivo, these PCs are unique and essential during developmen ...

American Society for Biochemistry and Molecular Biology2013