Concept

Cell damage

Publications associées (109)

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses

Vassily Hatzimanikatis, Meriç Ataman, Vikash Kumar Pandey

The expanding generation of dynamic biological data requires approaches that integrate and analyze information from different types of cellular processes –metabolism, regulation, and signaling–, and ultimately increase our insights into the cell behavior u ...

2017

Decellularization of bovine articular cartilage by supercritical carbon dioxide as a matrix for cartilage repair

Giulia Weissenberger

Decellularized extracellular matrix (ECM) derived scaﬀolds serve as potential candidates in the application of cartilage regeneration to guide cells into proliferating and maintaining the structural zones of articular cartilage. ECM tissue matrices oﬀer fr ...

2017

Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase

Joachim Lingner, Viesturs Simanis, Sophie Redon, Wareed Ahmed, Eric Aeby

Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and show th ...

Elsevier2016

GOLPH3 and oncogenesis: What is the molecular link?

Riccardo Rizzo

The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainl ...

2016

In-situ repair of composite sandwich structures using cyanoacrylates

Véronique Michaud, Paul Velut

A novel method for the in-situ repair of composite sandwich structures using microvascular networks and cyanoacrylate (CA) adhesive systems has been presented. Upon a damage event, the vascules become ruptured, providing a route for the introduction of adh ...

Elsevier Sci Ltd2016

Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome

Henning Paul-Julius Stahlberg, Simone Cavadini, Radosav Svetozara Pantelic

The cullin-RING ubiquitin E3 ligase (CRL) family comprises over 200 members in humans. The COP9 signalosome complex (CSN) regulates CRLs by removing their ubiquitin-like activator NEDD8. The CUL4A-RBX1-DDB1-DDB2 complex (CRL4A(DDB2)) monitors the genome fo ...

Springer Nature2016

Human audiometric thresholds do not predict specific cellular damage in the inner ear

Demetri Psaltis

Introduction: As otology enters the field of gene therapy and human studies commence, the question arises whether audiograms - the current gold standard for the evaluation of hearing function - can consistently predict cellular damage within the human inne ...

Elsevier2016

JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion In Vivo and after Hypoxia In Vitro

Tatiana Favez

Mitogen-activated protein kinases (MAPKs) are key regulators that have been linked to cell survival and death. Among the main classes of MAPKs, c-jun N-terminal kinase (JNK) has been shown to mediate cell stress responses associated with apoptosis. In Vitr ...

Springer Int Publishing Ag2016

Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis

Andrzej Sienkiewicz, Fanny Caputo

Efficient inorganic UV shields, mostly based on refracting TiO2 particles, have dramatically changed the sun exposure habits. Unfortunately, health concerns have emerged from the pro-oxidant photocatalytic effect of UV-irradiated TiO2, which mediates toxic ...

Royal Soc Chemistry2015

Program repair without regret

Barbara Jobstmann

We present a new and flexible approach to repair reactive programs with respect to a specification. The specification is given in linear-temporal logic. Like in previous approaches, we aim for a repaired program that satisfies the specification and is synt ...

Springer2015

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