Concept

Cellule souche neurale

Publications associées (296)

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

Maria del Carmen Sandi Perez, Hilal Lashuel, Lisa Conboy, Jorge Eduardo Castro Cifuentes

Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokin ...

Nature Publishing Group2011

A hybrid bio-organic interface for neuronal photo-activation

Diego Ghezzi

Interfacing artificial functional materials and living neuronal tissues is at the forefront of bio-nanotechnology. Attempts so far have been based on microscope processing of metals, inorganic semiconductors as electrodes or photoactive layers in biased de ...

2011

A hybrid approach for the control of axonal outgrowth: preliminary simulation results

Silvestro Micera

The possible control of axonal outgrowth during neural regeneration could be very useful not only from a neurobiological point of view, but also in the field of neural interfaces. In this manuscript, simulations are presented which investigate the possibil ...

2011

Genomic instability in induced stem cells

Didier Trono, Marc Samuel Friedli

The ability to reprogram adult cells into stem cells has raised hopes for novel therapies for many human diseases. Typical stem cell reprogramming protocols involve expression of a small number of genes in differentiated somatic cells with the c-Myc and Kl ...

Nature Publishing Group2011

Polarity mediates asymmetric trafficking of the G beta heterotrimeric G-protein subunit GPB-1 in C. elegans embryos

Pierre Gönczy, Kalyani Thyagarajan

Asymmetric cell division is an evolutionarily conserved process that gives rise to daughter cells with different fates. In one-cell stage C. elegans embryos, this process is accompanied by asymmetric spindle positioning, which is regulated by anterior-post ...

2011

2D Stem Cell Culture on Microfluidic Generated Hydrogel Beads

Tanja Cloé Hausherr

Stem cells capacity to self-renew and differentiate into specialized cell types, endow them with great promises in regenerative medicine. It is believed that the stem cells microenvironment plays a significant role in regulating their fate. However, with e ...

2011

Dll1- and Dll4-mediated Notch signaling is required for homeostasis of intestinal stem cells

Freddy Radtke, Ute Koch, Luca Pellegrinet, Shuang Chen

BACKGROUND & AIMS: Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors, due to their conversion into post-mitotic secretory cells. We aimed to confirm that Notch was active in stem cells (SC), inv ...

2011

Biomaterials meet microfluidics: building the next generation of artificial niches

Matthias Lütolf, Stefan Kobel

Biomaterials are increasingly being developed as in vitro microenvironments mimicking in vivo stem cell niches. However, current macroscale methodologies to produce these niche models fail to recapitulate the spatial and temporal characteristics of the com ...

Elsevier2011

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Liliane Glauser, Darren Moore, Klodjan Stafa, Ying Liu, David Ramonet Jimenez

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical fe ...

Public Library of Science2011

Clinical application of autologous epithelial stem cells in disorders of squamous epithelia

Yann Barrandon, Nicolas Grasset

Epidermis and epithelia lining the ocular surface, the oral cavity, the pharynx, the oesophagus, the larynx, and the vagina, called stratified squamous epithelia (SSE), contain stem/progenitor cells that support renewal and repair. Under appropriate condit ...

Humana Press2011

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