Concept

Antibiotique bêta-lactamine

Publications associées (130)

Using an adaptive gene network model for self-organizing multicellular behavior

Using the transient interleukin (IL)-2 secretion of effector T helper (Teff) cells as an example, we show that self-organizing multicellular behavior can be modeled and predicted by an adaptive gene network model. Incorporating an adaptation algorithm we e ...

IEEE2012

Dynamics of antibiotics concentrations in the environment at different time scales

David Andrew Barry, Luca Rossi, Sylvain Coutu, Vera Wyrsch

The aim of this study was to assess the most relevant time scales of antibiotics concentration variations at the sewage treatment plant (STP) inlet and to create a model for the simulation of short-term concentration variations. During one year six antibio ...

2012

Bicyclization and tethering to albumin yields long-acting Peptide antagonists

Christian Heinis, Alessandro Angelini, Shiyu Chen, Philippe Diderich, Julia Morales Sanfrutos

Proteolytically stable peptide architectures are required for the development of long-acting peptide therapeutics. In this work, we found that a phage-selected bicyclic peptide antagonist exhibits an unusually high stability in vivo and subsequently deciph ...

Amer Chemical Soc2012

Seasonal variations of antibiotics measured in the environment from sales data analysis

Luca Rossi, Sylvain Coutu, Jonas Margot, Christa McArdell

Antibiotics are substances commonly consumed by the population under medical prescriptions. These compounds may reach the environment through human excretion as they are partially eliminated in WWTPs. The occurrence of antibiotics in the aquatic environmen ...

2011

Deamidation and Transamidation of Substance P by Tissue Transglutaminase Revealed by Electron-Capture Dissociation Fourier Transform Mass Spectrometry (Chem. Eur. J. 2/2011)

Horst Vogel, Yury Tsybin, Luigino Grasso, Adrian Schmid, Luca Fornelli

Tissue transglutaminase (tTGase) catalyzes both deamidation and transamidation of peptides and proteins by using a peptidyl glutamine as primary substrate. A precise consensus sequence for the enzyme is unknown and the ratio between deamidated and transami ...

Wiley-Blackwell2011

Transformation of beta-Lactam Antibacterial Agents during Aqueous Ozonation: Reaction Pathways and Quantitative Bioassay of Biologically-Active Oxidation Products

Urs von Gunten

Reactions of ozone (O-3) with the beta-lactam antibiotics penicillin G (PG) and cephalexin (CP) have previously been found to yield products retaining antibacterial activities. These products are unequivocally identified here as the stereoisomeric (R)-sulf ...

2010

Kinetics of antimicrobial peptide activity measured on individual bacterial cells using high-speed atomic force microscopy

Georg Fantner

Observations of real-time changes in living cells have contributed much to the field of cellular biology. The ability to image whole, living cells with nanometre resolution on a timescale that is relevant to dynamic cellular processes has so far been elusi ...

2010

Common mechanistic features among metallo-β-lactamases: a computational study of Aeromonas hydrophila CphA enzyme

Matteo Dal Peraro, Andrea Cavalli, Paolo Carloni

Metallo-β-lactamases (MβLs) constitute an increasingly serious clinical threat by giving rise to β-lactam antibiotic resistance. They accommodate in their catalytic pocket one or two zinc ions, which are responsible for the hydrolysis of β-lactams. Recent ...

2009

Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis

Stewart Cole, Claudia Sala

Comparative genomics with Staphylococcus aureus suggested the existence of a regulatory system governing beta-lactamase (BlaC) production in Mycobacterium tuberculosis. The crystal structure of Rv1846c, a winged helix regulator of previously unknown functi ...

2009

Oxidation of Antibacterial Compounds by Ozone and Hydroxyl Radical: Elimination of Biological Activity during Aqueous Ozonation Processes

Urs von Gunten

A wide variety of antibacterial compounds is rapidly oxidized by O-3 and hydroxyl radical ((OH)-O-center dot) during aqueous ozonation. Quantitative microbiological assays have been developed here or adapted from existing methods and utilized to measure th ...

2009

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search