Concept

Mixed acid fermentation

Publications associées (32)

Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System

A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...

EPFL2011

Fuel bioethanol production from whey permeate

François-Nicolas de Glutz

The objective of this thesis was to evaluate the feasibility for the production of fuel bioethanol from whey permeate. The identification of the limiting factors of the process revealed that the stabilization of the substrate was critical to the use of whe ...

EPFL2009

Design and Optimization of a Lactate Amperometric Biosensor based on Lactate Oxidase and Multi Walled-Carbon Nanotubes

Giovanni De Micheli, Sandro Carrara, Cristina Boero

Lactate concentration in physiological fluids is an indicator of the energy production under anaerobic conditions of the whole organism [1]. Normal value for lactate level in blood ranges from 0.5 – 2.5 mM. Blood lactate values exceeding 7-8 mM are sometim ...

2008

Sustained neuronal activation raises oxidative metabolism to a new steady-state level: Evidence from 1H NMR spectroscopy in the human visual cortex

Rolf Gruetter

To date, functional 1H NMR spectroscopy has been utilized to report the time courses of few metabolites, primarily lactate. Benefiting from the sensitivity offered by ultra-high magnetic field (7 T), the concentrations of 17 metabolites were measured in th ...

2007

Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase

Pierre Magistretti, Luc Pellerin

BACKGROUND: For a long time now, glucose has been thought to be the main, if not the sole substrate for brain energy metabolism. Recent data nevertheless suggest that other molecules, such as monocarboxylates (lactate and pyruvate mainly) could be suitable ...

2007

Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Carmen Jungo

The objective of this thesis was to characterize the growth stoichiometry, the specific recombinant protein productivity and the regulation of the alcohol oxidase (AOX) enzyme of a Pichia pastoris Mut+ strain, performing conventional chemostat cultures and ...

EPFL2007

Use of coaxial photocatalytic reactor (CAPHORE) in the TiO2 photo-assisted treatment of mixed E-coli and Bacillus sp and bacterial community present in wastewater

César Pulgarin

This paper reports the photocatalytic disinfection of water contaminated by a mixture of Escherichia coli and Bacillus sp. as well as that of wastewater containing a larger microbial community. The photocatalytic reactions were carried out in a coaxial pho ...

2005

Fermentation by gut microbiota cultured in a simulator of the human intestinal microbial ecosystem is improved by supplementing a soygerm powder

Bart Deplancke

An in vitro model, designated the Simulator of the Human Intestinal Microbial Ecosystem (SHIME), was used to study the effect of a soygerm powder rich in beta-glycosidic phytoestrogenic isoflavones on the fermentation pattern of the colon microbiota and to ...

2000

Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging

Pierre Magistretti, Luc Pellerin

Despite striking advances in functional brain imaging, the cellular and molecular mechanisms that underlie the signals detected by these techniques are still largely unknown. The basic physiological principle of functional imaging is represented by the tig ...

1999

Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain

Pierre Magistretti, Jean-Luc Martin, Luc Pellerin

Under particular circumstances like lactation and fasting, the blood-borne monocarboxylates acetoacetate, beta-hydroxybutyrate, and lactate represent significant energy substrates for the brain. Their utilization is dependent on a transport system present ...

1998

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