Publications associées à Protéomique

Extended Bottom-Up Proteomics with Secreted Aspartic Protease Sap9

Yury Tsybin, Kristina Srzentic, Unige Anna Laskay

We investigate the benefits and experimental feasibility of approaches enabling the shift from short (1.7 kDa on average) peptides in bottom-up proteomics to about twice longer (similar to 3.2 kDa on average) peptides in the so-called extended bottom-up pr ...

Elsevier Science Bv2014

Comprehensive and Scalable Highly Automated MS-Based Proteomic Workflow for Clinical Biomarker Discovery in Human Plasma

Loïc Dayon, Martin Kussmann

Over the past decade, mass spectrometric performance has greatly improved in terms of sensitivity, dynamic range, and speed. By contrast, only limited progress has been accomplished with regard to automation, throughput, and robustness of the proteomic sam ...

Amer Chemical Soc2014

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Johan Auwerx, Evan Graehl Williams, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Ruedi Aebersold, Sébastien Dubuis

The manner by which genotype and environment affect complex phenotypes is one of the fundamental questions in biology. In this study, we quantified the transcriptome--a subset of the metabolome--and, using targeted proteomics, quantified a subset of the li ...

Cell Press2014

Proteome analysis of the response of Dehalobacter restrictus to cobalamin starvation

Christof Holliger, Julien Maillard, Aamani Rupakula Boyanapalli, Hauke Smidt

Dehalobacter restrictus strain PER-K23 is an obligate organohalide respiring microorganism known to solely use tetra- or trichloroethene as electron acceptors with H2 as electron donor. The catalytic enzyme, PceA, contains a corrinoid as cofactor, a trait ...

2014

Empirical multi-dimensional space for scoring peptide spectrum matches in shotgun proteomics

Yury Tsybin, Unige Anna Laskay

Data-dependent tandem mass spectrometry (MS/MS) is one of the main techniques for protein identification in shotgun proteomics. In a typical LC MS/MS workflow, peptide product ion mass spectra (MS/MS spectra) are compared with those derived theoretically f ...

Amer Chemical Soc2014

Principles of ChIP-seq Data Analysis Illustrated with Examples

Giovanna Ambrosini, Philipp Bucher, René Dreos

Chromatin immunoprecipitation (ChIP) followed by high-throughput sequencing (ChIP-seq) is a powerful method to determine how transcription factors and other chromatin-associated proteins interact with DNA in order to regulate gene transcription. A single C ...

Copicentro Granada S L2014

In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T

Rolf Gruetter, Cristina Ramona Cudalbu, Mélanie Craveiro

In 1H magnetic resonance spectroscopy, macromolecule signals underlay metabolite signals, the understanding of which is necessary for reliable metabolite quantification. When macromolecule signals are measured using an inversion-recovery pulse sequence, sp ...

Wiley-Blackwell2014

Proteome Digestion Specificity Analysis for Rational Design of Extended Bottom-up and Middle-down Proteomics Experiments

Yury Tsybin, Kristina Srzentic, Unige Anna Laskay

Mass spectrometry (MS)-based bottom-up proteomics (BUP) is currently the method of choice for large-scale identification and characterization of proteins present in complex samples, such as cell lysates, body fluids, or tissues. Technically, BUP relies on ...

Amer Chemical Soc2013

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Protéomique

Extended Bottom-Up Proteomics with Secreted Aspartic Protease Sap9

Comprehensive and Scalable Highly Automated MS-Based Proteomic Workflow for Clinical Biomarker Discovery in Human Plasma

From allergen detection to protein-ligand interactions

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Proteome analysis of the response of Dehalobacter restrictus to cobalamin starvation

Empirical multi-dimensional space for scoring peptide spectrum matches in shotgun proteomics

Principles of ChIP-seq Data Analysis Illustrated with Examples

In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T

Proteome Digestion Specificity Analysis for Rational Design of Extended Bottom-up and Middle-down Proteomics Experiments

Model Organisms Proteomics-From Holobionts to Human Nutrition

Graph Chatbot

Chattez avec Graph Search

From allergen detection to protein-ligand interactions

Model Organisms Proteomics-From Holobionts to Human Nutrition

Proteome analysis of the response of Dehalobacter restrictus to cobalamin starvation

Proteome Digestion Specificity Analysis for Rational Design of Extended Bottom-up and Middle-down Proteomics Experiments

Principles of ChIP-seq Data Analysis Illustrated with Examples

Empirical multi-dimensional space for scoring peptide spectrum matches in shotgun proteomics

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T