Concept

Industrie pharmaceutique

Publications associées (65)

Phosphopantetheinyl transferase-catalyzed formation of bioactive hydrogels for tissue engineering

Kai Johnsson, Matthias Lütolf, Katarzyna Mosiewicz

Synthetic bioactive hydrogels have been widely recognized as key elements of emerging strategies to engineer tissues. However, the current shortage of highly specific and biocompatible methods to form and functionalize these materials hampers their wide ph ...

American Chemical Society2010

Monitoring and optimization of industrial batch crystallization processes using NIR and ATR UV-vis spectroscopy

Julien Léo Billeter

In the pharmaceutical industry, batch crystallization processes at production scale are not always well understood. Several factors have a significant impact on the process of crystallization, such as the physicochemical properties (solubility curve and su ...

2010

Transient Gene Expression in Mammalian Cells: Promises and Challenges for Medical Biotechnology

Florian Maria Wurm, David Hacker, Lucia Baldi Unser

Recombinant protein-based biologics are increasingly relevant in the pharmaceutical industry. Currently, mammalian cell-based bioprocesses are a routine manufacturing procedure for complex proteins such as recombinant antibodies, and the number of new biol ...

Wiley2009

Phototransformation of selected pharmaceuticals during UV treatment of drinking water

Urs von Gunten, Silvio Canonica

The kinetics of Ultraviolet C (UV-C)-induced direct phototransformation of four representative pharmaceuticals, i.e., 17 alpha-ethinylestradiol (EE2), diclofenac, sulfa methoxazole, and iopromide, was investigated in dilute solutions of pure water buffered ...

2008

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis

Sebastian Maerkl

More effective therapies are urgently needed against hepatitis C virus (HCV), a major cause of viral hepatitis. We used in vitro protein expression and microfluidic affinity analysis to study RNA binding by the HCV transmembrane protein NS4B, which plays a ...

2008

Asymmetric total syntheses of ecteinascidin 597 and ecteinascidin 583

Jieping Zhu

The limited availability of bioactive natural products for pharmaceutical studies and drug development is a problem that can be solved, in principle, by total synthesis. The potent antitumor marine natural products ecteinascidin 597 (I; R = Me) and ecteina ...

2006

Determining a receptor-ligand interaction useful in e.g. drug screening involves repetitive application of reversibly binding fluorescent ligands with fast association-dissociation kinetics

Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Marinela Gjoni Boillat, Christoph Schreiter

NOVELTY - Determining a receptor-ligand interaction involves repeatedly contacting a cell comprising a receptor, with a ligand, of the receptor in which the ligand has a fluorescence labeling group and binds reversibly to the receptor under conditions in w ...

2006

Fluoronaphthalene building blocks via arynes: A solution to the problem of positional selectivity

Eric Masson

When 3-fluoro- and 3-chloro-1,2-didehydrobenzenes are generated in the presence of 2-(trimethylsilyl)furan, two regioisomeric cycloadducts are formed in a 1:2 ratio. However, regioselectivity can be installed by fitting one bulky trimethylsilyl group into ...

2005

Wastewaters

The major pathways of human pharmaceuticals into the environment are from their use by individuals either at home or under medical supervision in hospitals, and to a lesser extent by the disposal of unwanted or out of date drugs. The administered pharmaceu ...

EPFL2005

Tuberculosis: from genome to vaccine

Stewart Cole

The availability of mycobacterial genome sequences has paved the way to identifying potential tuberculosis vaccine candidates in order to replace the currently used bacillus Calmette-Guérin (BCG) vaccines that show variable protective efficacy in adults. G ...

2005

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