Concept

Bioluminescence imaging

Publications associées (21)

Silicon-on-Insulator Technology for Bioluminescence Imaging and Application to a Switching Photodetector

Maher Kayal, Adil Koukab, Denis Sallin, Nisrina Abdo

This paper analyzes some advantages of Silicon-on-Insulator (SOI) based photodetectors for bioluminescence imaging. It shows that SOI based sensors not only solve the bulk carriers problem, it can also act as a very selective spectral filter by acting as a ...

Ieee2015

Precursor molecule for the synthesis of d-luciferin

Aurélien Godinat

The present invention relates to precursor molecules for the synthesis of D-luciferin, or blocked D-luciferin and derivatives thereof, which are functionalized in different positions. Further, the use of functionalized precursor molecules for the synthesis ...

2015

Bioluminescence imaging of small biomolecules

Aurélien Godinat, Riccardo Sinisi, Grigory Karateev, Ghyslain Martial Alain Budin, Aleksandra Konovalova, Jens Tomas Frigell

The invention relates to a technique to detect small molecules using Bioluminescence imaging (BLI) to image and quantify non-invasively, in vitro and in vivo,intracellular metabolite fluxes and which can be applied to azido-modified compounds, such as azid ...

2014

A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animals

Aurélien Godinat, Alma Rosa Morales Morales, Ghyslain Martial Alain Budin

The great complexity of many human pathologies, such as cancer, diabetes, and neurodegenerative diseases, requires new tools for studies of biological processes on the whole organism level. The discovery of novel biocompatible reactions has tremendously ad ...

2014

Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors

Jeffrey Alan Hubbell, Mikaël Martino

In this work we have evaluated the capacity of bone morphogenetic protein-2 (BMP-2) and fibrin-binding platelet-derived growth factor-BB (PDGF-BB) to support cell growth and induce bone regeneration using two different imaging technologies to improve the u ...

Elsevier Sci Ltd2014

A Biocompatible in Vivo Ligation Reaction and Its Application for Noninvasive Bioluminescent Imaging of Protease Activity in Living Mice

Douglas Hanahan, Aurélien Godinat, Gennady Nikitin, Ke Cheng

The discovery of biocompatible reactions had a tremendous impact on chemical biology, allowing the study of numerous biological processes directly in complex systems. However, despite the fact that multiple biocompatible reactions have been developed in th ...

Amer Chemical Soc2013

Embryonic stem cell-based screen for small molecules: cluster analysis reveals four response patterns in developing neural cells

David Michael Suter, Mathurin Baquié

Neural differentiation of embryonic stem cells (ESC) is considered a promising model to perform in vitro testing for neuroactive and neurotoxic compounds. We studied the potential of a dual reporter murine ESC line to identify bioactive and/or toxic compou ...

2013

Real-Time Bioluminescence Imaging of Glycans on Live Cells

Cell-surface glycans are attractive targets for molecule imaging due to their reflection of cellular processes associated with development and disease progression. In this paper, we describe the design, synthesis, and biological application of a new phosph ...

American Chemical Society2010

Monitoring bone fetal cells seeded in PLA scaffolds using bioluminescence imaging

Alireza Roshan Ghias

In our laboratory, we have shown previously that bone fetal cells enhance osteogenesis in polymeric scaffolds. However, little is known about the longevity of these cells in vivo, and hence their function. A successful tissue engineering approach needs und ...

2010

Monitoring tumor response to radiation therapy with longitudinal and multimodal molecular imaging

Jessica Perez

Purpose: Metabolic changes induced by radiation therapy (RT) provide a biological measure of tumor response to treatment beyond anatomic changes. In this preclinical study we investigated these changes through longitudinal monitoring of tumor response to v ...

2010

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search