Concept
Syndrome extrapyramidal
Publications associées (33)
Non-Darwinian dynamics in therapy-induced cancer drug resistance
The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastabl ...
Nature Publishing Group2013Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes
Pierre Magistretti, Jean-Luc Martin, Igor Allaman
RATIONALE: The pharmacological actions of most antidepressants are ascribed to the modulation of serotonergic and/or noradrenergic transmission in the brain. During therapeutic treatment for major depression, fluoxetine, one of the most commonly prescribed ...
Springer Verlag2011A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2
Patrick Aebischer, Bernard Schneider, Romain Zufferey, Olexiy Kochubey, Klodjan Stafa, Julien Dusonchet
The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is the most common genetic cause of Parkinson's disease (PD), accounting for a significant proportion of both autosomal dominant familial and sporadic PD cases. Our aim in the present stu ...
Society for Neuroscience2011Novel organometallic ruthenium complexes for selective activation in tumour cells
In recent years, ruthenium-based antitumour drugs have emerged as an attractive alternative to cisplatin, exhibiting both excellent activity in tumours where cisplatin is of limited use and low general toxicity, leading to reduced side effects. Two rutheni ...
EPFL2010Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease
Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a ...
2009Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF
In spite of partial success in treating Parkinson's disease by using ectopically placed grafts of dopamine-producing cells, restoration of the original neuroanatomical circuits, if possible, might work better. Previous evidence of normal anatomic projectio ...
2009The relation between the general intellect of schizophrenic patients and psychopathological deterioration
Michael Herzog, Maya Roinishvili
Objectives: The aim of the study was to examine whether the postpsychotic decline in IQ during schizophrenia coincides with psychopathological deterioration or it is a state-independent premorbid impairment. Methods: The IQ score of 32 schizophrenic patien ...
2009Dopaminergic fiber protection and regeneration by Wlds protein and GDNF in rodent models of Parkinson disease
Parkinson disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. The resulting failure of the nigrostriatal pathway leads to profound dopamine deficiency, cau ...
EPFL2005Dopaminergic effects on encoding of a motor memory in chronic stroke
The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability ...
2005An ambulatory system to quantify bradykinesia and tremor in Parkinson's disease
Catherine Dehollain, Arash Salarian
Two groups of 10 Parkinson’s disease (PD) patients and 10 age-matched Normal subjects performing normal life activities were recorded using a portable recorder and 3D gyroscopes. PD patients had sub-thalamic stimulation implantation for 20±3 months. The PD ...
IEEE2003