Concept

Phosphoénolpyruvate carboxykinase

Publications associées (32)

Renal metabolism of hyperpolarized [1-13C]aspartate

Aspartic acid is involved in several central metabolic pathways, including gluconeogenesis, the urea cycle, de novo nucleotide synthesis, the malate-aspartate shuttle, and via transmination the TCA cycle. The conversion in vivo of hyperpolarized [1-13C]pyr ...

2018

Small Heterodimer Partner Deletion Prevents Hepatic Steatosis and When Combined With Farnesoid X Receptor Loss Protects Against Type 2 Diabetes in Mice

Kristina Schoonjans

Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are important regulators of bile acid, lipid, and glucose homeostasis. Here, we show that global Fxr(-/-) Shp(-/-) double knockout (DKO) mice are refractory to weight gain, gl ...

Wiley2017

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

Carlos Canto Alvarez, Joanna Ratajczak

Objective: Augmenting nicotinamide adenine dinucleotide (NAD(+)) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD(+) precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appe ...

Elsevier Science Bv2017

New optical tools for non-invasive imaging and quantification of glucose and nicotinamide riboside in living cells and animals

Aleksandra Konovalova

Glucose is one of the most important metabolites that plays a key role in living organisms, as it is the primary energy source. Glucose metabolism is also an integral part in the pathogenesis of diabetes and cancer. Despite this tremendous impact of glucos ...

EPFL2016

Direct dynamic measurement of intracellular and extracellular lactate in small-volume cell suspensions with 13C hyperpolarised NMR

Andrea Capozzi, Arnaud Comment

Hyperpolarised (HP) C-13 NMR allows enzymatic activity to be probed in real time in live biological systems. The use of in vitro models gives excellent control of the cellular environment, crucial in the understanding of enzyme kinetics. The increased conv ...

Wiley-Blackwell2015

Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments

Pierre Magistretti, Aurélie Delacrétaz

Weight gain is a major health problem among psychiatric populations. It implicates several receptors and hormones involved in energy balance and metabolism. Phosphoenolpyruvate carboxykinase 1 is a rate-controlling enzyme involved in gluconeogenesis, glyce ...

Lippincott, Williams & Wilkins2015

The Drosophila MAPK p38c Regulates Oxidative Stress and Lipid Homeostasis in the Intestine

Bruno Lemaitre, Sveta Chakrabarti

The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various su ...

Public Library of Science2014

Brain Glucose Transport and Phosphorylation Under Acute Insulin-Induced Hypoglycemia in Mice: An 18F-FDG PET Study

Rolf Gruetter, João Miguel das Neves Duarte, Malte Alf

We addressed the questions of how cerebral glucose transport and phosphorylation change under acute hypoglycemia and what the underlying mechanisms of adaptation are. Methods: Quantitative 18F-FDG PET combined with the acquisition of real-time arterial inp ...

2013

Manipulating redox and ATP balancing for improved production of succinate in E. coli

Vassily Hatzimanikatis, Keng Cher Soh

Redox and energy balance plays a key role in determining microbial fitness. Efforts to redirect bacterial metabolism often involve overexpression and deletion of genes surrounding key central metabolites, such as pyruvate and acetyl-coA. In the case of met ...

Elsevier2010

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

Johan Auwerx, Kristina Schoonjans, Ellen Helena Jeninga

rganisms adapt their metabolism to meet ever changing environmental conditions. This metabolic adaptation involves at a cellular level the fine tuning of mitochondrial function, which is mainly under the control of the transcriptional co-activator prolifer ...

2010

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