Concept
Acyl-coenzyme A déshydrogénase
Publications associées (17)
Ring-Opening Reactions of Aminocyclopropanes and Aminocyclobutanes
Nitrogen-containing compounds are an important class of molecules in medicinal chemistry, chemical biology, biochemistry, material sciences or environmental sciences. Organic nitrogen occurs in many forms, ranging from small building blocks such as urea, a ...
EPFL2022Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro, Laurence Gouzi Abrami, Florence Pojer, Sylvia Ho, Francisco De Magalhães Sarmento R De Mesquita, Patrick Alain Sandoz, Martina Audagnotto, Giulia Fonti, Muhammad Umair Anwar
Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation. Many biochemica ...
NATURE RESEARCH20211,3-Difunctionalization of Aminocyclopropanes via Dielectrophilic Intermediates
We report an oxidative ring-opening strategy to transform acyl, sulfonyl or carbamate protected aminocyclopropanes into 1,3-dielectrophilic carbon intermediates bearing a halide atom (Br, I) and a N,O-acetal. Replacing the alkoxy group of the N,O-acetal ca ...
2019Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function
Johan Auwerx, Zhi Li, Wei Chen, Dongryeol Ryu, Shuo Zhang
Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is regulated by sirtuin 5 (SIRT5). Although numerous proteins are modified by lysine succiny ...
Natl Acad Sciences2016GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution
Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take up glut ...
Elsevier2015The effects of globotriaosylceramide tail saturation level on bilayer phases
Globotriaosylceramide (Gb(3)) is a glycosphingolipid present in the plasma membrane that is the natural receptor of the bacterial Shiga toxin. The unsaturation level of Gb(3) acyl chains has a drastic impact on lipid bilayer properties and phase behaviour, ...
Royal Soc Chemistry2015Characterization of hepatic fatty acids in mice with reduced liver fat by ultra-short echo time (1) H-MRS at 14.1 T in vivo
Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares
Alterations in the hepatic lipid content (HLC) and fatty acid composition are associated with disruptions in whole body metabolism, both in humans and in rodent models, and can be non-invasively assessed by (1) H-MRS in vivo. We used (1) H-MRS to character ...
Wiley-Blackwell2015Towards a kinetic model of the phospholipids biosynthesis of the yeast Saccharomyces cerevisiae
Vassily Hatzimanikatis, Meriç Ataman, Georgios Savoglidis, Iro Oikonomidi
Lipids, as vital eukaryotic cellular components, play a major role in cell, tissue and organ physiology. Alterations of lipid enzymes and metabolic pathways are related to many human diseases, such as cancer, diabetes and neurodegenerative diseases. In thi ...
2014Impact of hepatic lipid accumulation and composition on glucose tolerance and insulin sensitivity: a longitudinal study in male and female mice
Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares
Background and aims: Metabolic disruptions characterized by high hepatic lipid content (HLC) are associated with impairments in whole body glucose homeostasis. To gain insight on the role of hepatic lipids in the metabolic performance in the absence artifi ...
Springer2014A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function
Johan Auwerx, Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Hongbo Zhang, Matthias Alexander Sokrates Stein, Giuseppe Lo Sasso
Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...
Cell Press2014