Acide bêta-hydroxybutyrique

Résumé

L’acide β-hydroxybutyrique, appelé β-hydroxybutyrate sous sa forme ionisée, est un composé chimique de formule . L'énantiomère D(–)-3-hydroxybutyrate est le corps cétonique le plus abondant. Il provient de l'acétoacétate ayant subi une hydrogénation réversible par la D(–)-3-hydroxybutyrate déshydrogénase. Il n'est pas détecté dans l'urine, contrairement à l'acétoacétate. Notes et références Voir aussi

Acide gamma-hydroxybutyrique
Poly-β-hydroxybutyrate

Hydroxybutyrique

Source officielle

https://fr.wikipedia.org/wiki/Acide_b%C3%AAta-hydroxybutyrique

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Publications associées (7)

Protein acetylation in metabolism - metabolites and cofactors

Johan Auwerx, Elena Katsyuba, Keir Joe Menzies, Hongbo Zhang

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolism, circadian rhythm and cell cycle, along with gene regulation in various organisms. The widespread and reversible nature of acetylation also revitalized interest in the mechanisms that regulate lysine acetyltransferases (KATs) and deacetylases (KDACs) in health and disease. Changes in protein or histone acetylation are especially relevant for many common diseases including obesity, diabetes mellitus, neurodegenerative diseases and cancer, as well as for some rare diseases such as mitochondrial diseases and lipodystrophies. In this Review, we examine the role of reversible acetylation in metabolic control and how changes in levels of metabolites or cofactors, including nicotinamide adenine dinucleotide, nicotinamide, coenzyme A, acetyl coenzyme A, zinc and butyrate and/or beta-hydroxybutyrate, directly alter KAT or KDAC activity to link energy status to adaptive cellular and organismal homeostasis.

Nature Publishing Group2016

Chargement

Protein acetylation in metabolism-metabolites and cofactors

Johan Auwerx, Elena Katsyuba, Keir Joe Menzies, Hongbo Zhang

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolism, circadian rhythm and cell cycle, along with gene regulation in various organisms. The widespread and reversible nature of acetylation also revitalized interest in the mechanisms that regulate lysine acetyltransferases (KATs) and deacetylases (KDACs) in health and disease. Changes in protein or histone acetylation are especially relevant for many common diseases including obesity, diabetes mellitus, neurodegenerative diseases and cancer, as well as for some rare diseases such as mitochondrial diseases and lipodystrophies. In this Review, we examine the role of reversible acetylation in metabolic control and how changes in levels of metabolites or cofactors, including nicotinamide adenine dinucleotide, nicotinamide, coenzyme A, acetyl coenzyme A, zinc and butyrate and/or β-hydroxybutyrate, directly alter KAT or KDAC activity to link energy status to adaptive cellular and organismal homeostasis. © 2015 Macmillan Publishers Limited. All rights reserved.

2015

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Nutritional Ketosis Increases NAD(+)/NADH Ratio in Healthy Human Brain: An in Vivo Study by P-31-MRS

Rolf Gruetter, Özlem Ipek, Mojgan Masoodi, Lijing Xin

2018

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Le cours "Microbiologie pour l'ingénieur" couvre les processus microbiens principaux qui ont lieu dans l'environnement et dans des systèmes de traitement. Il présente les cycles des éléments qui sont catalysés par des microorganismes et qui ont un impact important sur la planète Terre.

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