Publications associées à Dose létale

On the origin of primary 1/2 a(0) and a(0) loops in irradiated Fe(Cr) alloys

The radiation-induced primary dislocation loops in thin foils of ultra-high purity Fe and Fe(Cr) model alloys were investigated using ion irradiation in situ in a TEM. In the '111 mechanism' the induced nanometric loops of type a(0) stem from mutual ...

Pergamon-Elsevier Science Ltd2017

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Raphaël Doenlen, François Bochud, Gael Luis Boivin

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate ...

Elsevier Ireland Ltd2017

Measurement of metabolic changes in acute doxorubicin-induced cardiotoxicity in mice using hyperpolarized [1-13C]pyruvate

Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Emine Can

Chemotherapy cocktails containing doxorubicin produce irreversible cardiotoxic side effects that may progress to heart failure, which can only be avoided through dose limitation of the chemotherapeutic agents. Increasing evidence suggest that cardiac dysfu ...

2017

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

John McKinney, Neeraj Dhar, François Signorino-Gelo

Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of ison ...

Elsevier Science Bv2016

Optimization of drug combinations using Feedback System Control

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

We describe a protocol for the discovery of synergistic drug combinations for the treatment of disease. Synergistic drug combinations lead to the use of drugs at lower doses, which reduces side effects and can potentially lead to reduced drug resistance, w ...

Nature Publishing Group2016

Effects of PVA-coated nanoparticles on human T helper cell activity

Heinrich Hofmann, Lionel André Maurizi

Superparamagnetic iron oxide nanoparticles (SPION) are used as high-sensitive enhancer for magnetic resonance imaging, where they represent a promising tool for early diagnosis of destructive diseases such as rheumatoid arthritis (RA). Since we could demon ...

Elsevier2016

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique w ...

2015

Drug concentration prediction and delivery

Giovanni De Micheli, Alena Simalatsar, Wenqi You Dubout

In medical practice, the decision-making process regarding drug dose is critical to patients’ health and recovery. For drugs with narrow therapeutic ranges, the medical doctor decides the quantity (dose amount) and frequency (dose interval) on the basis of ...

2014

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Dose létale

On the origin of primary 1/2 a(0) and a(0) loops in irradiated Fe(Cr) alloys

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Oral application of Escherichia coli bacteriophage: safety tests in healthy and diarrheal children from Bangladesh

Measurement of metabolic changes in acute doxorubicin-induced cardiotoxicity in mice using hyperpolarized [1-13C]pyruvate

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

Optimization of drug combinations using Feedback System Control

Effects of PVA-coated nanoparticles on human T helper cell activity

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae

Drug concentration prediction and delivery

Graph Chatbot

Chattez avec Graph Search

Drug concentration prediction and delivery

Effects of PVA-coated nanoparticles on human T helper cell activity

Optimization of drug combinations using Feedback System Control

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae

On the origin of primary 1/2 a(0) and a(0) loops in irradiated Fe(Cr) alloys

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Oral application of Escherichia coli bacteriophage: safety tests in healthy and diarrheal children from Bangladesh