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Regenerative medicine requires innovative therapeutic designs to accommodate high morphogen concentrations in local depots, provide their sustained presence, and enhance cellular invasion and directed differentiation. Here we present an example for inducin ...
It has been established that primary stability of femoral stems is a determinant of the clinical success of cementless total hip arthroplasty[1]. Excessive interface micromotions may lead to a peri-implant fibrous tissue formation resulting in aseptic loos ...
Le projet vise à mettre en forme la notion de mixité sociale. Pour ce faire, il s'agit de créer un lieu de résidence où les classes moyennes et les classes moins aisées pourront cohabiter ensembles. Cette démarche cherche en premier à rompre le lien de cau ...
Blood stem cells, also termed hematopoietic stem cells (HSC), are used clinically to treat numerous blood cancers. However, due to the low numbers of HSCs that can be isolated from the bone marrow of donors, broad application of this treatment is severely ...
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The hematopoietic system is a regenerative tissue with high cell turnover. Normal homeostasis of the hematopoietic system is insured by hematopoietic stem cells (HSCs). The important features of HSCs are the capacity to self-renew and multipotency. Multipo ...
The phenotypic diversity of breast cancer has been proposed to result from different target cell types undergoing oncogenic transformation and giving rise to cancer stem cells. Global gene expression profiling revealed distinct molecular phenotypes and som ...
Nano-biosensing provides new tools to investigate cellular differentiation and proliferation. Upon the various metabolic compounds secreted by cells during life cycles, glucose, lactate and hydrogen peroxide (H2O2) are of first interest. Nanostructured ele ...
In the domain of regenerative medicine research there are many fronts aimed at increasing our understanding of induced pluripotent, embryonic and adult stem cells. Recently a new front has appeared, stem cell niches, the microenvironment that is a crucial ...
Myc activity is emerging as a key element in acquisition and maintenance of stem cell properties. We have previously shown that c-Myc deficiency results in accumulation of defective hematopoietic stem cells (HSCs) due to niche-dependent differentiation def ...
Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting that HSCs regularly enter and exit ...