Publications associées à Index of topics related to life extension

Multimodal transcriptomic atlases of mouse spinal cord injury

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

EPFL2024

L'aménagement du territoire comme espace public : quelques questions de démocratie locale posées par l’extension de l’École hôtelière dans le périurbain lausannois

Vincent Kaufmann, Luca Giovanni Pattaroni, Mischa-Sébastien Piraud

Based on a field survey on the conflicts regarding the extension of the Ecole Hôtelière de Lausanne, this text discusses the production of public space. These controversies make possible an understanding of the production process of peri-urban space in ter ...

2022

Statistical Fatigue Investigation and Failure Prediction of a Healable Composite System

Véronique Michaud, Amaël Maximilien Cohades, Nathan Klaus Hostettler

Fiber reinforced polymers are massively used as an alternative to metals in structural applications. The brittle nature of their matrix, however, makes them more susceptible to crack formation and propagation resulting in costly repair operations and incre ...

2020

Multi-omics reveals abundant mitochondrial genomic and circadian expression variation in the Drosophila Genetic Reference Panel

Maria Litovchenko

Modern biology rapidly generates a wealth of data,which can only be analysed computationally.Despite the variety of available data types,most of them aim to provide an answer to one question: how does genotypic diversity translates into phenotypes? This qu ...

EPFL2020

Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences

Carlos Canto Alvarez

Aging is the major risk factor for a constellation of multifactorial diseases, including insulin resistance, diabetes and cardiovascular complications. Dietary restriction has been shown to delay or prevent the manifestation of age-related health decline, ...

Cambridge Univ Press2016

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Carlos Canto Alvarez, Patrick Descombes, Sylviane Métairon

Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to delay age-related physiological decline in mammalian organisms. SIRT1, a NAD(+) -dependent deacetylase enzyme, has been suggested to mediate the adaptive responses to ...

Elsevier2016

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Johan Auwerx, Kristina Schoonjans, Matthias Lütolf, Davide D'Amico, Dongryeol Ryu, Xu Wang, Hongbo Zhang, Peiling Luan, Keir Joe Menzies, Karim Laurent Gariani

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

American Association for the Advancement of Science2016

Mitonuclear protein imbalance as a conserved longevity mechanism

Johan Auwerx, Graham Knott, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Joachim Lingner, Sophie Redon, Ivo Zemp

Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin. In vitro, naked TERRA molecules are efficient inhibitor ...

Oxford University Press2013

SRT1720 improves survival and healthspan of obese mice

Johan Auwerx, Carlos Canto Alvarez

Sirt1 is an NAD1-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate ...

Nature Publishing Group2011