Concept

Protéine plasmatique

Publications associées (41)

The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapy

The aim of the study is to evaluate the differences of protein binding of NAMI-A, a new ruthenium drug endowed with selective antimetastatic properties, and of cisplatin and to ascertain the possibility to use two drugs based on heavy metals in combination ...

2006

Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling

Kai Johnsson, Christian Heinis, Alexandre Juillerat, Christopher Chidley, Thomas Gronemeyer

The specific reaction of O6-alkylguanine-DNA alkyltransferase (AGT) with O6-benzylguanine (BG) derivatives allows for a specific labeling of AGT fusion proteins with chemically diverse compounds in living cells and in vitro. The efficiency of the labeling ...

Oxford University Press2006

A mass spectrometric and molecular modelling study of cisplatin binding to transferrin

Paul Joseph Dyson, Claire Samantha Allardyce

A combination of mass spectrometry, UV/Vis spectroscopy and molecular modelling techniques hove been used to characterise the interaction of cisplatin with human serum transferrin (Tf). Mass spectrometry indicates that cisplatin binds to the hydroxy functi ...

2005

Determination of drug binding sites to proteins by electrospray ionisation mass spectrometry: the interaction of cisplatin with transferrin

Paul Joseph Dyson, Claire Samantha Allardyce

Cisplatin, CiS-[PtCl2(NH3)(2)], is known to bind to human serum transferrin, but the binding site remains a matter of some debate. Electrospray ionisation mass spectrometry has been used to characterise the interaction of cisplatin with transferrin. The st ...

2002

In vivo observation of lactate methyl proton magnetization transfer in rat C6 glioma

Rolf Gruetter

Magnetic resonance spectroscopy (MRS) measurements of the lactate methyl proton in rat brain C6 glioma tissue acquired in the presence of an off- resonance irradiation field, analyzed using coupled Bloch equation formalism assuming two spin pools, demonstr ...

1999

Transport Studies for Ignition Experiments

The results of a predictive study of plasma energy confinement in Ignitor, performed with a 1 1/2-dimensional transport code and the Tang-Redi transport model, are reported. For comparison, performance predictions for the Next European Torus (NET), adoptin ...

1993

Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models

Johan Auwerx

Liver lipoprotein lipase (LPL) and alpha-fetoprotein (AFP) gene expression show similar developmental patterns. Both mRNAs are abundantly expressed in neonatal rat liver and gradually disappear upon ageing. Treatment with fibric acid derivatives, such as f ...

1992

Neonatal extinction of liver lipoprotein lipase expression

Johan Auwerx

In contrast to the complete absence of lipoprotein lipase (LPL) mRNA in adult rat liver, fetal and neonatal rat liver contain substantial amounts of LPL mRNA, which is translated in active LPL protein as can be deduced from the presence of LPL activity in ...

1992

Surface-immobilized polyethylene oxide for bacterial repellence

Jeffrey Alan Hubbell

Polyethylene terephthalate films were surface-modified with polyethylene oxide (18,500 g/mol) using a solution technique described previously. These films were investigated for their resistance to bacterial adhesion. Three bacterial strains most commonly a ...

1992

Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoprotein mRNA levels in rats

Johan Auwerx

Treatment of male rats with hydrocortisone provoked a dose- and time-dependent decrease in plasma cholesterol concentration without a change in plasma triglyceride levels. In contrast, administration of triamcinolone and dexamethasone at equipotent glucoco ...

1991

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